Telomerase and breast cancer

B. S. Herbert, W. E. Wright, J. W. Shay

Research output: Contribution to journalComment/debatepeer-review

58 Scopus citations

Abstract

Current therapies for breast cancer include treatments that are toxic and often result in drug resistance. Telomerase, a cellular reverse transcriptase that maintains the ends of chromosomes (telomeres), is activated in the vast majority of breast cancers (over 90% of breast carcinomas) but not in normal adjacent tissues. Telomerase is thus an attractive target for both diagnosis and therapy because of its distinct pattern of expression. We address the use of telomerase in the diagnostics of breast pathology, as well as the use of telomerase inhibitors in the treatment and prevention of breast cancer.

Original languageEnglish (US)
Pages (from-to)146-149
Number of pages4
JournalBreast Cancer Research
Volume3
Issue number3
DOIs
StatePublished - 2001

Keywords

  • Breast cancer
  • Inhibitors
  • Telomeres
  • Therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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