Telomerase and cancer

Jerry W. Shay, Ying Zou, Eiso Hiyama, Woodring E. Wright

Research output: Contribution to journalReview articlepeer-review

328 Scopus citations

Abstract

Telomerase, a eukaryotic ribonucleoprotein (RNP) complex, contains both an essential RNA and a protein reverse transcriptase subunit. By reverse transcription, the telomerase RNP maintains telomere length stability in almost all cancer cells. Over the past few years there has been significant progress in identifying the components of the telomerase holoenzyme complex and the proteins that associate with telomeres, in order to elucidate mechanisms of telomere length regulation. This review covers recent advances in the field including the use of telomerase in cancer diagnostics and an overview of anti-telomerase cancer therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)677-685
Number of pages9
JournalHuman molecular genetics
Volume10
Issue number7
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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