Telomerase: Anti-cancer target or just a fascinating enzyme?

Susan E. Hamilton; David R. Corey

doi:10.1016/S1074-5521(96)90173-8

Telomerase: Anti-cancer target or just a fascinating enzyme?

Susan E. Hamilton, David R. Corey

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

Telomerase activity is upregulated in most types of malignant tumor. Highly selective small molecule inhibitors will be needed to understand the biological basis for this observation and to determine if telomerase is a viable target for chemotherapy.

Original language	English (US)
Pages (from-to)	863-867
Number of pages	5
Journal	Chemistry and Biology
Volume	3
Issue number	11
DOIs	https://doi.org/10.1016/S1074-5521(96)90173-8
State	Published - 1996

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1016/S1074-5521(96)90173-8

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@article{0089780b10db4346821754890be193c8,

title = "Telomerase: Anti-cancer target or just a fascinating enzyme?",

abstract = "Telomerase activity is upregulated in most types of malignant tumor. Highly selective small molecule inhibitors will be needed to understand the biological basis for this observation and to determine if telomerase is a viable target for chemotherapy.",

author = "Hamilton, {Susan E.} and Corey, {David R.}",

note = "Funding Information: The authors thank members of the Corey laboratory and Dr Jerry Shay for their thoughtful comments on this manuscript. Support .for this work was provided by the Robert A Welch Foundation (l-1244) and by a CaP Cure research award. DRC is an Assistant Investigator with the Howard Hughes Medical Institute.",

year = "1996",

doi = "10.1016/S1074-5521(96)90173-8",

language = "English (US)",

volume = "3",

pages = "863--867",

journal = "Chemistry and Biology",

issn = "1074-5521",

publisher = "Elsevier Inc.",

number = "11",

}

TY - JOUR

T1 - Telomerase

T2 - Anti-cancer target or just a fascinating enzyme?

AU - Hamilton, Susan E.

AU - Corey, David R.

N1 - Funding Information: The authors thank members of the Corey laboratory and Dr Jerry Shay for their thoughtful comments on this manuscript. Support .for this work was provided by the Robert A Welch Foundation (l-1244) and by a CaP Cure research award. DRC is an Assistant Investigator with the Howard Hughes Medical Institute.

PY - 1996

Y1 - 1996

N2 - Telomerase activity is upregulated in most types of malignant tumor. Highly selective small molecule inhibitors will be needed to understand the biological basis for this observation and to determine if telomerase is a viable target for chemotherapy.

AB - Telomerase activity is upregulated in most types of malignant tumor. Highly selective small molecule inhibitors will be needed to understand the biological basis for this observation and to determine if telomerase is a viable target for chemotherapy.

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U2 - 10.1016/S1074-5521(96)90173-8

DO - 10.1016/S1074-5521(96)90173-8

M3 - Review article

C2 - 8939712

AN - SCOPUS:0030292846

SN - 1074-5521

VL - 3

SP - 863

EP - 867

JO - Chemistry and Biology

JF - Chemistry and Biology

IS - 11

ER -

Telomerase: Anti-cancer target or just a fascinating enzyme?

Abstract

ASJC Scopus subject areas

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