Telomerase as a therapeutic target in cancer

Ginelle C. Gellert, Shalmica R. Jackson, Z. Gunnur Dikmen, Woodring E. Wright, Jerry W. Shay

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

Advances in chromosome dynamics have increased our understanding of the significant role of telomeres and telomerase in cancer. Telomerase is expressed in almost all cancer cells but is inactive in most normal somatic cells. Therefore, telomerase is an important target for the design of therapeutic agents that might have minimal side effects. Herein, we evaluate current approaches to telomerase-targeted therapy, discuss the benefits and disadvantages, and speculate on the future direction of telomerase inhibitors as cancer therapeutics.

Original languageEnglish (US)
Pages (from-to)159-164
Number of pages6
JournalDrug Discovery Today: Disease Mechanisms
Volume2
Issue number2
DOIs
StatePublished - Dec 1 2005

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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