Telomerase inhibitors

Laura K. White, Woodring E. Wright, Jerry W. Shay

Research output: Contribution to journalArticle

186 Citations (Scopus)

Abstract

There has been a vast increase in telomerase research over the past several years, with many different pre-clinical approaches being tested for inhibiting the activity of this enzyme as a novel therapeutic modality to treat malignancy. In this review, we will provide some basic background information about telomeres and telomerase and then discuss the pros, cons and challenges of the approaches that are currently under investigation, and what we might expect in the future of this emerging field.

Original languageEnglish (US)
Pages (from-to)114-120
Number of pages7
JournalTrends in Biotechnology
Volume19
Issue number3
DOIs
StatePublished - Mar 1 2001

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Telomerase
Enzymes
Telomere
Research
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Bioengineering

Cite this

Telomerase inhibitors. / White, Laura K.; Wright, Woodring E.; Shay, Jerry W.

In: Trends in Biotechnology, Vol. 19, No. 3, 01.03.2001, p. 114-120.

Research output: Contribution to journalArticle

White, Laura K. ; Wright, Woodring E. ; Shay, Jerry W. / Telomerase inhibitors. In: Trends in Biotechnology. 2001 ; Vol. 19, No. 3. pp. 114-120.
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