Telomerase inhibitors

Laura K. White; Woodring E. Wright; Jerry W. Shay

doi:10.1016/S0167-7799(00)01541-9

Telomerase inhibitors

Laura K. White, Woodring E. Wright, Jerry W. Shay

Research output: Contribution to journal › Review article › peer-review

200 Scopus citations

Abstract

There has been a vast increase in telomerase research over the past several years, with many different pre-clinical approaches being tested for inhibiting the activity of this enzyme as a novel therapeutic modality to treat malignancy. In this review, we will provide some basic background information about telomeres and telomerase and then discuss the pros, cons and challenges of the approaches that are currently under investigation, and what we might expect in the future of this emerging field.

Original language	English (US)
Pages (from-to)	114-120
Number of pages	7
Journal	Trends in Biotechnology
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/S0167-7799(00)01541-9
State	Published - Mar 1 2001

ASJC Scopus subject areas

Biotechnology
Bioengineering

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10.1016/S0167-7799(00)01541-9

Cite this

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title = "Telomerase inhibitors",

abstract = "There has been a vast increase in telomerase research over the past several years, with many different pre-clinical approaches being tested for inhibiting the activity of this enzyme as a novel therapeutic modality to treat malignancy. In this review, we will provide some basic background information about telomeres and telomerase and then discuss the pros, cons and challenges of the approaches that are currently under investigation, and what we might expect in the future of this emerging field.",

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AU - Shay, Jerry W.

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AB - There has been a vast increase in telomerase research over the past several years, with many different pre-clinical approaches being tested for inhibiting the activity of this enzyme as a novel therapeutic modality to treat malignancy. In this review, we will provide some basic background information about telomeres and telomerase and then discuss the pros, cons and challenges of the approaches that are currently under investigation, and what we might expect in the future of this emerging field.

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DO - 10.1016/S0167-7799(00)01541-9

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Telomerase inhibitors

Abstract

ASJC Scopus subject areas

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