Telomere dynamics in macaques and humans

Jeffrey P. Gardner, Masayuki Kimura, Weihang Chai, Jameel F. Durrani, Levon Tchakmakjian, Xiaojian Cao, Xiaobin Lu, Guanghui Li, Athanasios P. Peppas, Joan Skurnick, Woodring E. Wright, Jerry W. Shay, Abraham Aviv

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

In humans, telomere length in proliferating tissues shortens with age - a process accelerated with age-related diseases. Thus, telomere length and attrition with age in the nonhuman primate may serve as a useful paradigm for understanding telomere biology in humans. We examined telomere parameters in tissues of young and old Macaca fascicularis and compared them with several tissues from humans. Macaque telomeres were variable in length and exhibited partial synchrony (equivalence) within animals. They were longer than humans, partially because of longer subtelomeric segments. As skeletal muscle telomere length was unchanged with age, we used it as an internal reference to offset interanimal variation in telomere length. We identified age-dependent telomere attrition in lung, pancreas, skin, and thyroid. Similar to humans, telomerase activity was detected in spleen, thymus, digestive tract, and gonads. We conclude that factors that modify telomere attrition and aging in humans may also operate in the macaque.

Original languageEnglish (US)
Pages (from-to)367-374
Number of pages8
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume62
Issue number4
StatePublished - Apr 2007

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Telomere
Macaca
Macaca fascicularis
Telomerase
Gonads
Human Activities
Thymus Gland
Primates
Gastrointestinal Tract
Pancreas
Thyroid Gland
Skeletal Muscle
Spleen
Lung
Skin

ASJC Scopus subject areas

  • Aging

Cite this

Gardner, J. P., Kimura, M., Chai, W., Durrani, J. F., Tchakmakjian, L., Cao, X., ... Aviv, A. (2007). Telomere dynamics in macaques and humans. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 62(4), 367-374.

Telomere dynamics in macaques and humans. / Gardner, Jeffrey P.; Kimura, Masayuki; Chai, Weihang; Durrani, Jameel F.; Tchakmakjian, Levon; Cao, Xiaojian; Lu, Xiaobin; Li, Guanghui; Peppas, Athanasios P.; Skurnick, Joan; Wright, Woodring E.; Shay, Jerry W.; Aviv, Abraham.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 62, No. 4, 04.2007, p. 367-374.

Research output: Contribution to journalArticle

Gardner, JP, Kimura, M, Chai, W, Durrani, JF, Tchakmakjian, L, Cao, X, Lu, X, Li, G, Peppas, AP, Skurnick, J, Wright, WE, Shay, JW & Aviv, A 2007, 'Telomere dynamics in macaques and humans', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 62, no. 4, pp. 367-374.
Gardner JP, Kimura M, Chai W, Durrani JF, Tchakmakjian L, Cao X et al. Telomere dynamics in macaques and humans. Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2007 Apr;62(4):367-374.
Gardner, Jeffrey P. ; Kimura, Masayuki ; Chai, Weihang ; Durrani, Jameel F. ; Tchakmakjian, Levon ; Cao, Xiaojian ; Lu, Xiaobin ; Li, Guanghui ; Peppas, Athanasios P. ; Skurnick, Joan ; Wright, Woodring E. ; Shay, Jerry W. ; Aviv, Abraham. / Telomere dynamics in macaques and humans. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2007 ; Vol. 62, No. 4. pp. 367-374.
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