Telomere positional effects and the regulation of cellular senescence

Woodring E. Wright; Jerry W. Shay

doi:10.1016/0168-9525(92)90232-S

Telomere positional effects and the regulation of cellular senescence

Woodring E. Wright, Jerry W. Shay

Research output: Contribution to journal › Article › peer-review

245 Scopus citations

Abstract

Normal cells have a limited capacity to proliferate but the molecular clock that regulates the onset of cellular senescence remains unidentified. The ends of chromosomes-telomeres - have been shown to shorten progressively with age in normal cells. Here, were present a working model of how telomeric shortening may induce programmed changes in the regulation of cellular proliferation.

Original language	English (US)
Pages (from-to)	193-197
Number of pages	5
Journal	Trends in Genetics
Volume	8
Issue number	6
DOIs	https://doi.org/10.1016/0168-9525(92)90232-S
State	Published - Jun 1992

ASJC Scopus subject areas

Genetics

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10.1016/0168-9525(92)90232-S

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title = "Telomere positional effects and the regulation of cellular senescence",

abstract = "Normal cells have a limited capacity to proliferate but the molecular clock that regulates the onset of cellular senescence remains unidentified. The ends of chromosomes-telomeres - have been shown to shorten progressively with age in normal cells. Here, were present a working model of how telomeric shortening may induce programmed changes in the regulation of cellular proliferation.",

author = "Wright, {Woodring E.} and Shay, {Jerry W.}",

note = "Funding Information: This work was supportedb y NIH grants (W.E.W.a ndJ .W.S.)a ndC A50195(J .W.S.).",

year = "1992",

month = jun,

doi = "10.1016/0168-9525(92)90232-S",

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journal = "Trends in Genetics",

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T1 - Telomere positional effects and the regulation of cellular senescence

AU - Wright, Woodring E.

AU - Shay, Jerry W.

N1 - Funding Information: This work was supportedb y NIH grants (W.E.W.a ndJ .W.S.)a ndC A50195(J .W.S.).

PY - 1992/6

Y1 - 1992/6

N2 - Normal cells have a limited capacity to proliferate but the molecular clock that regulates the onset of cellular senescence remains unidentified. The ends of chromosomes-telomeres - have been shown to shorten progressively with age in normal cells. Here, were present a working model of how telomeric shortening may induce programmed changes in the regulation of cellular proliferation.

AB - Normal cells have a limited capacity to proliferate but the molecular clock that regulates the onset of cellular senescence remains unidentified. The ends of chromosomes-telomeres - have been shown to shorten progressively with age in normal cells. Here, were present a working model of how telomeric shortening may induce programmed changes in the regulation of cellular proliferation.

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Telomere positional effects and the regulation of cellular senescence

Abstract

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