Telomere positional effects and the regulation of cellular senescence

Woodring E. Wright, Jerry W. Shay

Research output: Contribution to journalArticle

230 Citations (Scopus)

Abstract

Normal cells have a limited capacity to proliferate but the molecular clock that regulates the onset of cellular senescence remains unidentified. The ends of chromosomes-telomeres - have been shown to shorten progressively with age in normal cells. Here, were present a working model of how telomeric shortening may induce programmed changes in the regulation of cellular proliferation.

Original languageEnglish (US)
Pages (from-to)193-197
Number of pages5
JournalTrends in Genetics
Volume8
Issue number6
DOIs
StatePublished - 1992

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Cell Aging
Telomere
Chromosomes
Cell Proliferation

ASJC Scopus subject areas

  • Genetics

Cite this

Telomere positional effects and the regulation of cellular senescence. / Wright, Woodring E.; Shay, Jerry W.

In: Trends in Genetics, Vol. 8, No. 6, 1992, p. 193-197.

Research output: Contribution to journalArticle

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