Telomeres and telomerase

N. M V Gomes, J. W. Shay, W. E. Wright

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations

Abstract

Telomere-based replicative senescence is thought to function as a potent mechanism of tumor protection in humans. Whether this mechanism is conserved in other species is still unclear. In this review we present an inter-species critical overview of some of the available literature on the fundamental biology of telomeres and telomerase during development, regeneration, cancer and aging of living organisms during their evolutionary journey through time.

Original languageEnglish (US)
Title of host publicationThe Comparative Biology of Aging
PublisherSpringer Netherlands
Pages227-258
Number of pages32
ISBN (Print)9789048134649
DOIs
StatePublished - Dec 1 2010

Keywords

  • Amphibians
  • Birds
  • Evolution
  • Fish
  • Invertebrates
  • Mammals
  • Telomerase
  • Telomeres
  • Vertebrates

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

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    Gomes, N. M. V., Shay, J. W., & Wright, W. E. (2010). Telomeres and telomerase. In The Comparative Biology of Aging (pp. 227-258). Springer Netherlands. https://doi.org/10.1007/978-90-481-3465-6-11