Telomeres and Telomerase: From Discovery to Clinical Trials

Research output: Contribution to journalComment/debate

31 Scopus citations

Abstract

Telomeres are the ends of linear chromosomes. They cannot be fully replicated by standard polymerases and are maintained by the ribonucleoprotein telomerase. Telomeres and telomerase stand at a junction of critical processes underlying chromosome integrity, cancer, and aging, and their importance was recognized by the 2009 Nobel Prize in Physiology or Medicine to Elizabeth Blackburn, Jack Szostak, and Carol Greider. Where will the field go now? What are the prospects for antitelomerase agents as drugs? Nearly 30 years after Szostak and Blackburn's pioneering manuscript on telomere ends, the challenges of discovery remain.

Original languageEnglish (US)
Pages (from-to)1219-1223
Number of pages5
JournalChemistry and Biology
Volume16
Issue number12
DOIs
StatePublished - Dec 24 2009

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Keywords

  • CELLBIO
  • CHEMBIO

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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