Temperature-sensitive polymer-coated magnetic nanoparticles as a potential drug delivery system for targeted therapy of thyroid cancer

Bhanuprasanth Koppolu, Zarna Bhavsar, Aniket S. Wadajkar, Sivaniarvindpriya Nattama, Maham Rahimi, Fiemu Nwariaku, Kytai T. Nguyen

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

The objective of this work was to develop and investigate temperature-sensitive poly(N-isopropylacrylamide-acrylamide-allylamine)-coated iron oxide magnetic nanoparticles (TPMNPs) as possible targeted drug carriers for treatments of advanced thyroid cancer (ATC). These nanoparticles were prepared by free radical polymerization of monomers on the surface of silane-coupled iron oxide nanoparticles. In vitro studies demonstrated that TPMNPs were cytocompatible and effectively taken up by cancer cells in a dose-dependent manner. An external magnetic field significantly increased nanoparticle uptake, especially when cells were exposed to physiological flow conditions. Drug loading and release studies using doxorubicin confirmed the temperature-responsive release of drugs from nanoparticles. In addition, doxorubicin-loaded nanoparticles significantly killed ATC cells when compared to free doxorubicin. The in vitro results indicate that TPMNPs have potential as targeted and controlled drug carriers for thyroid cancer treatment.

Original languageEnglish (US)
Pages (from-to)983-990
Number of pages8
JournalJournal of biomedical nanotechnology
Volume8
Issue number6
DOIs
StatePublished - Dec 1 2012

Keywords

  • Magnetic nanoparticles
  • On-off drug release
  • Temperature-Responsive polymers
  • Thyroid cancer

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Temperature-sensitive polymer-coated magnetic nanoparticles as a potential drug delivery system for targeted therapy of thyroid cancer'. Together they form a unique fingerprint.

  • Cite this