TY - JOUR
T1 - Temperature-sensitive polymer-coated magnetic nanoparticles as a potential drug delivery system for targeted therapy of thyroid cancer
AU - Koppolu, Bhanuprasanth
AU - Bhavsar, Zarna
AU - Wadajkar, Aniket S.
AU - Nattama, Sivaniarvindpriya
AU - Rahimi, Maham
AU - Nwariaku, Fiemu
AU - Nguyen, Kytai T.
PY - 2012/12
Y1 - 2012/12
N2 - The objective of this work was to develop and investigate temperature-sensitive poly(N-isopropylacrylamide-acrylamide-allylamine)-coated iron oxide magnetic nanoparticles (TPMNPs) as possible targeted drug carriers for treatments of advanced thyroid cancer (ATC). These nanoparticles were prepared by free radical polymerization of monomers on the surface of silane-coupled iron oxide nanoparticles. In vitro studies demonstrated that TPMNPs were cytocompatible and effectively taken up by cancer cells in a dose-dependent manner. An external magnetic field significantly increased nanoparticle uptake, especially when cells were exposed to physiological flow conditions. Drug loading and release studies using doxorubicin confirmed the temperature-responsive release of drugs from nanoparticles. In addition, doxorubicin-loaded nanoparticles significantly killed ATC cells when compared to free doxorubicin. The in vitro results indicate that TPMNPs have potential as targeted and controlled drug carriers for thyroid cancer treatment.
AB - The objective of this work was to develop and investigate temperature-sensitive poly(N-isopropylacrylamide-acrylamide-allylamine)-coated iron oxide magnetic nanoparticles (TPMNPs) as possible targeted drug carriers for treatments of advanced thyroid cancer (ATC). These nanoparticles were prepared by free radical polymerization of monomers on the surface of silane-coupled iron oxide nanoparticles. In vitro studies demonstrated that TPMNPs were cytocompatible and effectively taken up by cancer cells in a dose-dependent manner. An external magnetic field significantly increased nanoparticle uptake, especially when cells were exposed to physiological flow conditions. Drug loading and release studies using doxorubicin confirmed the temperature-responsive release of drugs from nanoparticles. In addition, doxorubicin-loaded nanoparticles significantly killed ATC cells when compared to free doxorubicin. The in vitro results indicate that TPMNPs have potential as targeted and controlled drug carriers for thyroid cancer treatment.
KW - Magnetic nanoparticles
KW - On-off drug release
KW - Temperature-Responsive polymers
KW - Thyroid cancer
UR - http://www.scopus.com/inward/record.url?scp=84865310340&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865310340&partnerID=8YFLogxK
U2 - 10.1166/jbn.2012.1465
DO - 10.1166/jbn.2012.1465
M3 - Article
C2 - 23030006
AN - SCOPUS:84865310340
SN - 1550-7033
VL - 8
SP - 983
EP - 990
JO - Journal of biomedical nanotechnology
JF - Journal of biomedical nanotechnology
IS - 6
ER -