Temporal changes in the outcomes of patients with diabetes mellitus undergoing percutaneous coronary intervention in the National Heart, Lung, and Blood Institute dynamic registry

Elizabeth M. Holper, J. Dawn Abbott, Suresh Mulukutla, Helen Vlachos, Faith Selzer, Darren K McGuire, David P. Faxon, Warren Laskey, Vankeepuram S. Srinivas, Oscar C. Marroquin, Alice K. Jacobs

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Background: Patients with diabetes mellitus (DM) are at higher risk for adverse outcomes following percutaneous coronary intervention (PCI). Methods: To determine whether outcomes have improved over time, we analyzed data from 2,838 consecutive patients with medically treated DM, including 1,066 patients (37.6%) treated with insulin, in the National Heart, Lung, and Blood Institute Dynamic Registry undergoing PCI registered in waves 1 (1997-1998), 2 (1999), 3 (2001-2002), 4 (2004), and 5 (2006). We compared baseline demographics and 1-year outcomes in the overall cohort and in analyses stratified by recruitment wave and insulin use. Results: Crude mortality rates by chronological wave were 9.5%, 12.5%, 8.9%, 11.6%, and 6.6% (P valuetrend = .33) among those treated with insulin and, respectively, 9.7%, 6.5%, 4.1%, 5.4%, and 4.7% (P valuetrend = .006) among patients treated with oral agents,. The adjusted hazard ratios of death, myocardial infarction (MI), and overall major adverse cardiovascular events (death, MI, revascularization) in insulin-treated patients with DM in waves 2 to 5 as compared with wave 1 were either higher or the same. In contrast, the similar adjusted hazard ratios for oral agent-treated patients with DM were either similar or lower. Conclusions: Significant improvements over time in adverse events by 1 year were detected in patients with DM treated with oral agents. In insulin-treated diabetic patients, despite lower rates of repeat revascularization over time, death and MI following PCI have not significantly improved. These findings underscore the need for continued efforts at optimizing outcomes among patients with DM undergoing PCI, especially those requiring insulin treatment.

Original languageEnglish (US)
Pages (from-to)397-403.e1
JournalAmerican heart journal
Volume161
Issue number2
DOIs
StatePublished - Feb 2011

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Holper, E. M., Abbott, J. D., Mulukutla, S., Vlachos, H., Selzer, F., McGuire, D. K., Faxon, D. P., Laskey, W., Srinivas, V. S., Marroquin, O. C., & Jacobs, A. K. (2011). Temporal changes in the outcomes of patients with diabetes mellitus undergoing percutaneous coronary intervention in the National Heart, Lung, and Blood Institute dynamic registry. American heart journal, 161(2), 397-403.e1. https://doi.org/10.1016/j.ahj.2010.11.004