Temporal course of gas exchange and mechanical compensation after right pneumonectomy in immature dogs

S. Takeda, E. Y. Wu, M. Ramanathan, A. S. Estrera, C. C W Hsia

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

To determine the temporal progression and magnitude of functional compensation in immature dogs raised to maturity after extensive lung resection, we performed right pneumonectomy (R-Pnx) or right thoracotomy without pneumonectomy (Sham) in matched foxhounds at 2 mo of age. At 4, 8, 20, 40, and 60 wk after surgery, static transpulmonary pressure-lung volume relationships were determined. Lung diffusing capacity, membrane diffusing capacity, pulmonary capillary blood volume, pulmonary blood flow, septal lung tissue volume, and lung volumes were measured simultaneously by a rebreathing technique. During maturation, total lung capacity, lung volume at a given distending pressure, and compliance were lower in the R-Pnx group than in the Sham group (P < 0.05). Pulmonary viscous resistance at maturity was elevated after R-Pnx. There were no significant differences in total lung diffusing capacity, membrane diffusing capacity, pulmonary capillary blood volume, pulmonary blood flow, and septal lung tissue volume between groups. Compensation of alveolarcapillary gas exchange was complete by 4-8 wk after R-Pnx, but compensation of mechanical properties remained incomplete throughout maturation. Relative magnitude of compensation after R-Pnx was greater in immature dogs than in adult dogs studied previously by similar techniques.

Original languageEnglish (US)
Pages (from-to)1304-1312
Number of pages9
JournalJournal of Applied Physiology
Volume80
Issue number4
StatePublished - Apr 1996

Fingerprint

Pneumonectomy
Gases
Dogs
Lung
Pulmonary Diffusing Capacity
Total Lung Capacity
Blood Volume
Lung Volume Measurements
Pressure
Membranes
Thoracotomy
Compliance

Keywords

  • capillary blood volume
  • diffusing capacity
  • growth
  • lung compliance
  • lung resection
  • lung volume
  • maturation
  • membrane diffusing capacity
  • pressure-volume relationship
  • viscous resistance

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Temporal course of gas exchange and mechanical compensation after right pneumonectomy in immature dogs. / Takeda, S.; Wu, E. Y.; Ramanathan, M.; Estrera, A. S.; Hsia, C. C W.

In: Journal of Applied Physiology, Vol. 80, No. 4, 04.1996, p. 1304-1312.

Research output: Contribution to journalArticle

Takeda, S. ; Wu, E. Y. ; Ramanathan, M. ; Estrera, A. S. ; Hsia, C. C W. / Temporal course of gas exchange and mechanical compensation after right pneumonectomy in immature dogs. In: Journal of Applied Physiology. 1996 ; Vol. 80, No. 4. pp. 1304-1312.
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