Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis

Katherine Noelani Chang; Shan Zhong; Matthew T. Weirauch; Gary Hon; Mattia Pelizzola; Hai Li; Shao Shan Carol Huang; Robert J. Schmitz; Mark A. Urich; Dwight Kuo; Joseph R. Nery; Hong Qiao; Ally Yang; Abdullah Jamali; Huaming Chen; Trey Ideker; Bing Ren; Ziv Bar-Joseph; Timothy R. Hughes; Joseph R. Ecker

doi:10.7554/eLife.00675

Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis

Katherine Noelani Chang, Shan Zhong, Matthew T. Weirauch, Gary Hon, Mattia Pelizzola, Hai Li, Shao Shan Carol Huang, Robert J. Schmitz, Mark A. Urich, Dwight Kuo, Joseph R. Nery, Hong Qiao, Ally Yang, Abdullah Jamali, Huaming Chen, Trey Ideker, Bing Ren, Ziv Bar-Joseph, Timothy R. Hughes, Joseph R. Ecker

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306 Scopus citations

Abstract

The gaseous plant hormone ethylene regulates a multitude of growth and developmental processes. How the numerous growth control pathways are coordinated by the ethylene transcriptional response remains elusive. We characterized the dynamic ethylene transcriptional response by identifying targets of the master regulator of the ethylene signaling pathway, ETHYLENE INSENSITIVE3 (EIN3), using chromatin immunoprecipitation sequencing and transcript sequencing during a timecourse of ethylene treatment. Ethylene-induced transcription occurs in temporal waves regulated by EIN3, suggesting distinct layers of transcriptional control. EIN3 binding was found to modulate a multitude of downstream transcriptional cascades, including a major feedback regulatory circuitry of the ethylene signaling pathway, as well as integrating numerous connections between most of the hormone mediated growth response pathways. These findings provide direct evidence linking each of the major plant growth and development networks in novel ways. Copyright Chang et al.

Original language	English (US)
Article number	e00675
Journal	eLife
Volume	2013
Issue number	2
DOIs	https://doi.org/10.7554/eLife.00675
State	Published - Jun 11 2013

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology

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Chang, K. N., Zhong, S., Weirauch, M. T., Hon, G., Pelizzola, M., Li, H., Carol Huang, S. S., Schmitz, R. J., Urich, M. A., Kuo, D., Nery, J. R., Qiao, H., Yang, A., Jamali, A., Chen, H., Ideker, T., Ren, B., Bar-Joseph, Z., Hughes, T. R., & Ecker, J. R. (2013). Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis. eLife, 2013(2), Article e00675. https://doi.org/10.7554/eLife.00675

Chang, KN, Zhong, S, Weirauch, MT, Hon, G, Pelizzola, M, Li, H, Carol Huang, SS, Schmitz, RJ, Urich, MA, Kuo, D, Nery, JR, Qiao, H, Yang, A, Jamali, A, Chen, H, Ideker, T, Ren, B, Bar-Joseph, Z, Hughes, TR & Ecker, JR 2013, 'Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis', eLife, vol. 2013, no. 2, e00675. https://doi.org/10.7554/eLife.00675

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abstract = "The gaseous plant hormone ethylene regulates a multitude of growth and developmental processes. How the numerous growth control pathways are coordinated by the ethylene transcriptional response remains elusive. We characterized the dynamic ethylene transcriptional response by identifying targets of the master regulator of the ethylene signaling pathway, ETHYLENE INSENSITIVE3 (EIN3), using chromatin immunoprecipitation sequencing and transcript sequencing during a timecourse of ethylene treatment. Ethylene-induced transcription occurs in temporal waves regulated by EIN3, suggesting distinct layers of transcriptional control. EIN3 binding was found to modulate a multitude of downstream transcriptional cascades, including a major feedback regulatory circuitry of the ethylene signaling pathway, as well as integrating numerous connections between most of the hormone mediated growth response pathways. These findings provide direct evidence linking each of the major plant growth and development networks in novel ways. Copyright Chang et al.",

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AU - Jamali, Abdullah

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AB - The gaseous plant hormone ethylene regulates a multitude of growth and developmental processes. How the numerous growth control pathways are coordinated by the ethylene transcriptional response remains elusive. We characterized the dynamic ethylene transcriptional response by identifying targets of the master regulator of the ethylene signaling pathway, ETHYLENE INSENSITIVE3 (EIN3), using chromatin immunoprecipitation sequencing and transcript sequencing during a timecourse of ethylene treatment. Ethylene-induced transcription occurs in temporal waves regulated by EIN3, suggesting distinct layers of transcriptional control. EIN3 binding was found to modulate a multitude of downstream transcriptional cascades, including a major feedback regulatory circuitry of the ethylene signaling pathway, as well as integrating numerous connections between most of the hormone mediated growth response pathways. These findings provide direct evidence linking each of the major plant growth and development networks in novel ways. Copyright Chang et al.

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Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis

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