Temporally specified genetic ablation of neurogenesis impairs cognitive recovery after traumatic brain injury

Cory A. Blaiss, Tzong Shiue Yu, Gui Zhang, Jian Chen, Georgi Dimchev, Luis F. Parada, Craig M. Powell, Steven G. Kernie

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Significant spontaneous recovery occurs after essentially all forms of serious brain injury, although the mechanisms underlying this recovery are unknown. Given that many forms of brain injury such as traumatic brain injury (TBI) induce hippocampal neurogenesis, we investigated whether these newly generated neurons might play a role in recovery. By modeling TBI in transgenic mice, we determined that injury-induced newly generated neurons persisted over time and elaborated extensive dendritic trees that stably incorporated themselves throughout all neuronal layers of the dentate gyrus. When we selectively ablated dividing stem/progenitors at the time of injury with ganciclovir in a nestin-HSV-TK transgenic model, we eliminated injury-induced neurogenesis and subsequently diminished the progenitor pool. Moreover, using hippocampal-specific behavioral tests, we demonstrated that only injured animals with neurogenesis ablated at the time of injury lost the ability to learn spatial memory tasks. These data demonstrate a functional role for adult neurogenesis after brain injury and offer compelling and testable therapeutic options that might enhance recovery.

Original languageEnglish (US)
Pages (from-to)4906-4916
Number of pages11
JournalJournal of Neuroscience
Volume31
Issue number13
DOIs
StatePublished - Mar 30 2011

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Neurogenesis
Brain Injuries
Wounds and Injuries
Neurons
Nestin
Ganciclovir
Aptitude
Dentate Gyrus
Transgenic Mice
Traumatic Brain Injury
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Blaiss, C. A., Yu, T. S., Zhang, G., Chen, J., Dimchev, G., Parada, L. F., ... Kernie, S. G. (2011). Temporally specified genetic ablation of neurogenesis impairs cognitive recovery after traumatic brain injury. Journal of Neuroscience, 31(13), 4906-4916. https://doi.org/10.1523/JNEUROSCI.5265-10.2011

Temporally specified genetic ablation of neurogenesis impairs cognitive recovery after traumatic brain injury. / Blaiss, Cory A.; Yu, Tzong Shiue; Zhang, Gui; Chen, Jian; Dimchev, Georgi; Parada, Luis F.; Powell, Craig M.; Kernie, Steven G.

In: Journal of Neuroscience, Vol. 31, No. 13, 30.03.2011, p. 4906-4916.

Research output: Contribution to journalArticle

Blaiss, CA, Yu, TS, Zhang, G, Chen, J, Dimchev, G, Parada, LF, Powell, CM & Kernie, SG 2011, 'Temporally specified genetic ablation of neurogenesis impairs cognitive recovery after traumatic brain injury', Journal of Neuroscience, vol. 31, no. 13, pp. 4906-4916. https://doi.org/10.1523/JNEUROSCI.5265-10.2011
Blaiss, Cory A. ; Yu, Tzong Shiue ; Zhang, Gui ; Chen, Jian ; Dimchev, Georgi ; Parada, Luis F. ; Powell, Craig M. ; Kernie, Steven G. / Temporally specified genetic ablation of neurogenesis impairs cognitive recovery after traumatic brain injury. In: Journal of Neuroscience. 2011 ; Vol. 31, No. 13. pp. 4906-4916.
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