TERF2-XPF: Caught in the middle; beginnings from the end

Lisa D. McDaniel, Roger A. Schultz, Errol C. Friedberg

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Two recent articles suggest new roles for the TERF2-XPF complex (a.k.a. TRF2-XPF)11We take the liberty of referring to new evidence regarding the ERCC1-XPF complex, when the actual data has examined XPF only. in the recognition/repair of DNA damage at non-telomeric chromosomal locations (i.e. "Caught in the Middle"). These new roles for proteins typically ascribed functions at the ends of chromosomes are proposed to be very early events of DNA damage response (i.e. Beginnings from the End). Our previous understanding of a role for the TERF2-XPF complex in the maintenance of chromosome stability included the preservation of telomere length by "suppression" of the recognition of chromosome ends as breaks. One recent paper demonstrates that TERF2 also functions at non-telomeric sites of DNA damage, and does so prior to initiation of the ATM signaling cascade. A second paper goes on to demonstrate that overexpression of TERF2 produces mouse phenotypes similar to those associated with xeroderma pigmentosum, such as cellular hypersensitivity to UV radiation and DNA crosslinking agents, and telomere shortening and chromosome instability in response to DNA damage. Moreover, data are presented illustrating that these abnormal responses are not seen in an XPF-/- background, consistent with a dependency on XPF. Interestingly, both manuscripts focus on events that transpire in response to exogenous DNA damage. Here, we review these exciting findings that suggest new roles for the TERF2-XPF complex and point out several questions that remain to be addressed.

Original languageEnglish (US)
Pages (from-to)868-872
Number of pages5
JournalDNA Repair
Volume5
Issue number7
DOIs
StatePublished - Jul 13 2006

Fingerprint

DNA Damage
Chromosomes
DNA
Chromosomal Instability
Telomere Shortening
Xeroderma Pigmentosum
Manuscripts
Telomere
Automatic teller machines
Hypersensitivity
Ultraviolet radiation
Crosslinking
Maintenance
Radiation
Repair
Phenotype
Proteins

Keywords

  • Mouse models
  • Telomere maintenance
  • TERF2/TRF2
  • UV-radiation response
  • XPF

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

TERF2-XPF : Caught in the middle; beginnings from the end. / McDaniel, Lisa D.; Schultz, Roger A.; Friedberg, Errol C.

In: DNA Repair, Vol. 5, No. 7, 13.07.2006, p. 868-872.

Research output: Contribution to journalArticle

McDaniel, Lisa D. ; Schultz, Roger A. ; Friedberg, Errol C. / TERF2-XPF : Caught in the middle; beginnings from the end. In: DNA Repair. 2006 ; Vol. 5, No. 7. pp. 868-872.
@article{d33071f6696a444393ddf9dca04651d9,
title = "TERF2-XPF: Caught in the middle; beginnings from the end",
abstract = "Two recent articles suggest new roles for the TERF2-XPF complex (a.k.a. TRF2-XPF)11We take the liberty of referring to new evidence regarding the ERCC1-XPF complex, when the actual data has examined XPF only. in the recognition/repair of DNA damage at non-telomeric chromosomal locations (i.e. {"}Caught in the Middle{"}). These new roles for proteins typically ascribed functions at the ends of chromosomes are proposed to be very early events of DNA damage response (i.e. Beginnings from the End). Our previous understanding of a role for the TERF2-XPF complex in the maintenance of chromosome stability included the preservation of telomere length by {"}suppression{"} of the recognition of chromosome ends as breaks. One recent paper demonstrates that TERF2 also functions at non-telomeric sites of DNA damage, and does so prior to initiation of the ATM signaling cascade. A second paper goes on to demonstrate that overexpression of TERF2 produces mouse phenotypes similar to those associated with xeroderma pigmentosum, such as cellular hypersensitivity to UV radiation and DNA crosslinking agents, and telomere shortening and chromosome instability in response to DNA damage. Moreover, data are presented illustrating that these abnormal responses are not seen in an XPF-/- background, consistent with a dependency on XPF. Interestingly, both manuscripts focus on events that transpire in response to exogenous DNA damage. Here, we review these exciting findings that suggest new roles for the TERF2-XPF complex and point out several questions that remain to be addressed.",
keywords = "Mouse models, Telomere maintenance, TERF2/TRF2, UV-radiation response, XPF",
author = "McDaniel, {Lisa D.} and Schultz, {Roger A.} and Friedberg, {Errol C.}",
year = "2006",
month = "7",
day = "13",
doi = "10.1016/j.dnarep.2006.03.012",
language = "English (US)",
volume = "5",
pages = "868--872",
journal = "DNA Repair",
issn = "1568-7864",
publisher = "Elsevier",
number = "7",

}

TY - JOUR

T1 - TERF2-XPF

T2 - Caught in the middle; beginnings from the end

AU - McDaniel, Lisa D.

AU - Schultz, Roger A.

AU - Friedberg, Errol C.

PY - 2006/7/13

Y1 - 2006/7/13

N2 - Two recent articles suggest new roles for the TERF2-XPF complex (a.k.a. TRF2-XPF)11We take the liberty of referring to new evidence regarding the ERCC1-XPF complex, when the actual data has examined XPF only. in the recognition/repair of DNA damage at non-telomeric chromosomal locations (i.e. "Caught in the Middle"). These new roles for proteins typically ascribed functions at the ends of chromosomes are proposed to be very early events of DNA damage response (i.e. Beginnings from the End). Our previous understanding of a role for the TERF2-XPF complex in the maintenance of chromosome stability included the preservation of telomere length by "suppression" of the recognition of chromosome ends as breaks. One recent paper demonstrates that TERF2 also functions at non-telomeric sites of DNA damage, and does so prior to initiation of the ATM signaling cascade. A second paper goes on to demonstrate that overexpression of TERF2 produces mouse phenotypes similar to those associated with xeroderma pigmentosum, such as cellular hypersensitivity to UV radiation and DNA crosslinking agents, and telomere shortening and chromosome instability in response to DNA damage. Moreover, data are presented illustrating that these abnormal responses are not seen in an XPF-/- background, consistent with a dependency on XPF. Interestingly, both manuscripts focus on events that transpire in response to exogenous DNA damage. Here, we review these exciting findings that suggest new roles for the TERF2-XPF complex and point out several questions that remain to be addressed.

AB - Two recent articles suggest new roles for the TERF2-XPF complex (a.k.a. TRF2-XPF)11We take the liberty of referring to new evidence regarding the ERCC1-XPF complex, when the actual data has examined XPF only. in the recognition/repair of DNA damage at non-telomeric chromosomal locations (i.e. "Caught in the Middle"). These new roles for proteins typically ascribed functions at the ends of chromosomes are proposed to be very early events of DNA damage response (i.e. Beginnings from the End). Our previous understanding of a role for the TERF2-XPF complex in the maintenance of chromosome stability included the preservation of telomere length by "suppression" of the recognition of chromosome ends as breaks. One recent paper demonstrates that TERF2 also functions at non-telomeric sites of DNA damage, and does so prior to initiation of the ATM signaling cascade. A second paper goes on to demonstrate that overexpression of TERF2 produces mouse phenotypes similar to those associated with xeroderma pigmentosum, such as cellular hypersensitivity to UV radiation and DNA crosslinking agents, and telomere shortening and chromosome instability in response to DNA damage. Moreover, data are presented illustrating that these abnormal responses are not seen in an XPF-/- background, consistent with a dependency on XPF. Interestingly, both manuscripts focus on events that transpire in response to exogenous DNA damage. Here, we review these exciting findings that suggest new roles for the TERF2-XPF complex and point out several questions that remain to be addressed.

KW - Mouse models

KW - Telomere maintenance

KW - TERF2/TRF2

KW - UV-radiation response

KW - XPF

UR - http://www.scopus.com/inward/record.url?scp=33745288539&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745288539&partnerID=8YFLogxK

U2 - 10.1016/j.dnarep.2006.03.012

DO - 10.1016/j.dnarep.2006.03.012

M3 - Article

C2 - 16762604

AN - SCOPUS:33745288539

VL - 5

SP - 868

EP - 872

JO - DNA Repair

JF - DNA Repair

SN - 1568-7864

IS - 7

ER -