Terminal deoxynucleotidyl transferase activity in childhood leukemia

N. Winick, P. G. Steinherz, D. R. Miller

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The activity of terminal deoxynucleotidyl transferase (Tdt) was measured in mononuclear cells of 70 children with acute leukemia, in whom raised levels of Tdt were noted at diagnosis, relapse, or during remission. Serial measurements of Tdt activity were related to the percentage of blasts in the bone marrow and the clinical course of children both during therapy and after its completion. The Tdt values did not predict relapse in children with acute lymphoblastic leukemia nor did the quantitative determination correlate with the percentage of blasts in the bone marrow.

Original languageEnglish (US)
Pages (from-to)1943-1947
Number of pages5
JournalCancer
Volume55
Issue number9
DOIs
StatePublished - May 1 1985

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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