Terminal deoxynucleotidyl transferase activity in childhood leukemia

N. Winick; P. G. Steinherz; D. R. Miller

doi:10.1002/1097-0142(19850501)55:9<1943::AID-CNCR2820550919>3.0.CO;2-9

Terminal deoxynucleotidyl transferase activity in childhood leukemia

N. Winick, P. G. Steinherz, D. R. Miller

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The activity of terminal deoxynucleotidyl transferase (Tdt) was measured in mononuclear cells of 70 children with acute leukemia, in whom raised levels of Tdt were noted at diagnosis, relapse, or during remission. Serial measurements of Tdt activity were related to the percentage of blasts in the bone marrow and the clinical course of children both during therapy and after its completion. The Tdt values did not predict relapse in children with acute lymphoblastic leukemia nor did the quantitative determination correlate with the percentage of blasts in the bone marrow.

Original language	English (US)
Pages (from-to)	1943-1947
Number of pages	5
Journal	Cancer
Volume	55
Issue number	9
DOIs	https://doi.org/10.1002/1097-0142(19850501)55:9<1943::AID-CNCR2820550919>3.0.CO;2-9
State	Published - May 1 1985

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/1097-0142(19850501)55:9<1943::AID-CNCR2820550919>3.0.CO;2-9

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title = "Terminal deoxynucleotidyl transferase activity in childhood leukemia",

abstract = "The activity of terminal deoxynucleotidyl transferase (Tdt) was measured in mononuclear cells of 70 children with acute leukemia, in whom raised levels of Tdt were noted at diagnosis, relapse, or during remission. Serial measurements of Tdt activity were related to the percentage of blasts in the bone marrow and the clinical course of children both during therapy and after its completion. The Tdt values did not predict relapse in children with acute lymphoblastic leukemia nor did the quantitative determination correlate with the percentage of blasts in the bone marrow.",

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T1 - Terminal deoxynucleotidyl transferase activity in childhood leukemia

AU - Winick, N.

AU - Steinherz, P. G.

AU - Miller, D. R.

PY - 1985/5/1

Y1 - 1985/5/1

N2 - The activity of terminal deoxynucleotidyl transferase (Tdt) was measured in mononuclear cells of 70 children with acute leukemia, in whom raised levels of Tdt were noted at diagnosis, relapse, or during remission. Serial measurements of Tdt activity were related to the percentage of blasts in the bone marrow and the clinical course of children both during therapy and after its completion. The Tdt values did not predict relapse in children with acute lymphoblastic leukemia nor did the quantitative determination correlate with the percentage of blasts in the bone marrow.

AB - The activity of terminal deoxynucleotidyl transferase (Tdt) was measured in mononuclear cells of 70 children with acute leukemia, in whom raised levels of Tdt were noted at diagnosis, relapse, or during remission. Serial measurements of Tdt activity were related to the percentage of blasts in the bone marrow and the clinical course of children both during therapy and after its completion. The Tdt values did not predict relapse in children with acute lymphoblastic leukemia nor did the quantitative determination correlate with the percentage of blasts in the bone marrow.

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DO - 10.1002/1097-0142(19850501)55:9<1943::AID-CNCR2820550919>3.0.CO;2-9

M3 - Article

C2 - 3978575

AN - SCOPUS:0021925226

SN - 0008-543X

VL - 55

SP - 1943

EP - 1947

JO - Cancer

JF - Cancer

IS - 9

ER -

Terminal deoxynucleotidyl transferase activity in childhood leukemia

Abstract

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