Terminal deoxynucleotidyl transferase (TdT)-containing peripheral blood mononuclear cells during remission of acute lymphoblastic leukemia: Low sensitivity and specificity prevent accurate prediction of relapse

Maxine L. Hetherington, Polly R. Huntsman, R. Graham Smith, George R. Buchanan

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Serial samples of peripheral blood were obtained from 75 children with acute lymphoblastic leukemia in remission. An immunofluorescence assay was used to quantitative TdT-containing (terminal deoxynucleotidyl transferase-containing) cells in the mononuclear leukocyte fraction of these specimens. Nine relapses in 8 patients were preceded by elevations (0.12-0.70%) in peripheral blood terminal deoxynucleotidyl transferase-containing cells noted 1-33 weeks prior to relapse. No such elevations were observed prior to 6 relapses in 4 patients. Peripheral blood terminal transferase deoxynucleotidyl-containing cells were elevated (0.12-0.61%) in 22 children who did not relapse over a 5-82 week period of observation. The sensitivity (67%) and specificity (68%) of this assay are inadequate to establish which patients have minimal residual leukemia.

Original languageEnglish (US)
Pages (from-to)537-543
Number of pages7
JournalLeukemia Research
Volume11
Issue number6
DOIs
StatePublished - 1987

Keywords

  • Terminal deoxynucleotidyl transferase
  • acute lymphoblastic leukemia
  • minimal residual disease

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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