TERT promoter mutations enhance telomerase activation by long-range chromatin interactions

Jaewon Min, Jerry W. Shay

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Although single-nucleotide somatic mutations in the proximal promoter of the human telomerase reverse transcriptase (TERT) gene create novel consensus sequences for transcription factors that enhance TERT expression, the precise mechanism of how telomerase is reactivated in cancer cells remains poorly understood. In this issue, Akıncılar and colleagues identify a potential mechanism of TERT reactivation that is mediated by a novel long-range chromatin interaction between the TERT promoter on chromosome 5p and a 300-kb upstream region. This permits recruitment of the transcription factor GABPA in mutant TERT promoters but not in wild-type promoters.

Original languageEnglish (US)
Pages (from-to)1212-1214
Number of pages3
JournalCancer Discovery
Volume6
Issue number11
DOIs
Publication statusPublished - Nov 1 2016

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ASJC Scopus subject areas

  • Oncology

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