Test-retest assessment of cortical activation induced by repetitive transcranial magnetic stimulation with brain atlas-guided optical topography

Fenghua Tian, F. Andrew Kozel, Amarnath Yennu, Paul E. Croarkin, Shawn M. McClintock, Kimberly S. Mapes, Mustafa M. Husain, Hanli Liu

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is a technology that stimulates neurons with rapidly changing magnetic pulses with demonstrated therapeutic applications for various neuropsychiatric disorders. Functional near-infrared spectroscopy (fNIRS) is a suitable tool to assess rTMS-evoked brain responses without interference from the magnetic or electric fields generated by the TMS coil. We have previously reported a channel-wise study of combined rTMS/fNIRS on the motor and prefrontal cortices, showing a robust decrease of oxygenated hemoglobin concentration (Δ[HbO2]) at the sites of 1-Hz rTMS and the contralateral brain regions. However, the reliability of this putative clinical tool is unknown. In this study, we develop a rapid optical topography approach to spatially characterize the rTMS-evoked hemodynamic responses on a standard brain atlas. A hemispherical approximation of the brain is employed to convert the three-dimensional topography on the complex brain surface to a two-dimensional topography in the spherical coordinate system. The test-retest reliability of the combined rTMS/fNIRS is assessed using repeated measurements performed two to three days apart. The results demonstrate that the Δ[HbO2] amplitudes have moderate-to-high reliability at the group level; and the spatial patterns of the topographic images have high reproducibility in size and a moderate degree of overlap at the individual level.

Original languageEnglish (US)
Article number116020
JournalJournal of Biomedical Optics
Volume17
Issue number11
DOIs
StatePublished - Nov 2012

Fingerprint

stimulation
Topography
brain
Brain
topography
Chemical activation
Near infrared spectroscopy
activation
infrared spectroscopy
hemodynamic responses
Hemoglobin
Hemodynamics
spherical coordinates
cortexes
Neurons
hemoglobin
neurons
Hemoglobins
Electric fields
Magnetic fields

Keywords

  • deoxygenated hemoglobin
  • functional near-infrared spectroscopy
  • individual analysis
  • oxygenated hemoglobin
  • reliability
  • repetitive transcranial magnetic stimulation
  • topography

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Test-retest assessment of cortical activation induced by repetitive transcranial magnetic stimulation with brain atlas-guided optical topography. / Tian, Fenghua; Kozel, F. Andrew; Yennu, Amarnath; Croarkin, Paul E.; McClintock, Shawn M.; Mapes, Kimberly S.; Husain, Mustafa M.; Liu, Hanli.

In: Journal of Biomedical Optics, Vol. 17, No. 11, 116020, 11.2012.

Research output: Contribution to journalArticle

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