Tetanus in pregnancy

Jeanne S. Sheffield, Susan M. Ramin

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Tetanus remains a leading cause of maternal and neonatal morbidity and mortality in developing countries. It is caused by the release of two toxins produced by Clostridium tetani, a noninvasive gram-positive anaerobic bacillus. Tetanospasmin is taken up by the neuronal end plates and prevents neurotransmitter release at the synaptic junction. This leads to spasm and is irreversible. Recovery requires the formation of new neurons and may take months. Generalized muscle spasm, respiratory compromise, and autonomic dysfunction are all common clinical manifestations. Diagnosis is based mainly on history and clinical examination. The management of the pregnant woman is similar to the nonpregnant individual. The main objectives are prompt prevention of further toxin absorption, wound debridement, antibiotic therapy, and aggressive supportive care. Primary and secondary prevention protocols are important worldwide because tetanus is a preventable disease. The tetanus toxoid vaccine can be given in pregnancy.

Original languageEnglish (US)
Pages (from-to)173-182
Number of pages10
JournalAmerican Journal of Perinatology
Volume21
Issue number4
DOIs
StatePublished - May 2004

Fingerprint

Tetanus
Spasm
Tetanus Toxoid
Pregnancy
Tetanus Toxin
Infant Mortality
Debridement
Primary Prevention
Secondary Prevention
Bacillus
Developing Countries
Neurotransmitter Agents
Pregnant Women
History
Mothers
Anti-Bacterial Agents
Morbidity
Neurons
Wounds and Injuries
Therapeutics

Keywords

  • Clostridium tetani
  • Pregnancy
  • Tetanus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Sheffield, J. S., & Ramin, S. M. (2004). Tetanus in pregnancy. American Journal of Perinatology, 21(4), 173-182. https://doi.org/10.1055/s-2004-828605

Tetanus in pregnancy. / Sheffield, Jeanne S.; Ramin, Susan M.

In: American Journal of Perinatology, Vol. 21, No. 4, 05.2004, p. 173-182.

Research output: Contribution to journalArticle

Sheffield, JS & Ramin, SM 2004, 'Tetanus in pregnancy', American Journal of Perinatology, vol. 21, no. 4, pp. 173-182. https://doi.org/10.1055/s-2004-828605
Sheffield, Jeanne S. ; Ramin, Susan M. / Tetanus in pregnancy. In: American Journal of Perinatology. 2004 ; Vol. 21, No. 4. pp. 173-182.
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