How the structurally distinct transcription factor TFIIS from eukaryotes and its bacterial counterpart GreB act to convert their cognate RNA polymerases into ribonucleases has been a longstanding question. Now, two new structures of these factors bound to their respective RNA polymerases (Opalka et al. and Kettenberger et al. [this issue of Cell]) suggest how they accomplish this feat.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)