TY - JOUR
T1 - TGF-β family signaling in mesenchymal differentiation
AU - Grafe, Ingo
AU - Alexander, Stefanie
AU - Peterson, Jonathan R.
AU - Snider, Taylor Nicholas
AU - Levi, Benjamin
AU - Lee, Brendan
AU - Mishina, Yuji
N1 - Funding Information:
We thank all the excellent scientists and reviewers in the field for their tremendous and inspirational work. We apologize sincerely to those colleagues whose work we have not cited because of space limitations. We like to thank Patricia Fonseca for editorial assistance. This work was supported by the National Institutes of Health (NIH) Grants 1F31DE024693- 01 (S.A.), 1K08GM109105-01 (Be.L.), P01 HD70394 (Br.L.), and R01 DE020843 to (Y.M.). The mCT core at the School of Dentistry, University of Michigan, is supported in part by NIH/NCRR S10RR026475-01. This work was also supported by a Michael Geisman Fellowship from the Osteogenesis Imperfecta Foundation (I.G.), the Plastic Surgery Foundation National Endowment Award (Be.L.), International FOP Association (Y.M., Be.L.), the Baylor College of Medicine Intellectual and Developmental Disabilities Research Center (HD024064), and the Rolanette and Berdon Lawrence Bone Disease Program of Texas.
Publisher Copyright:
© 2018 Cold Spring Harbor Laboratory Press; all rights reserved.
PY - 2018/5
Y1 - 2018/5
N2 - Mesenchymal stem cells (MSCs) can differentiate into several lineages during development and also contribute to tissue homeostasis and regeneration, although the requirements for both may be distinct. MSC lineage commitment and progression in differentiation are regulated by members of the transforming growth factor-β (TGF-β) family. This review focuses on the roles of TGF-β family signaling in mesenchymal lineage commitment and differentiation into osteoblasts, chondrocytes, myoblasts, adipocytes, and tenocytes.We summarize the reported findings of cell culture studies, animal models, and interactions with other signaling pathways and highlight how aberrations in TGF-β family signaling can drive human disease by affecting mesenchymal differentiation.
AB - Mesenchymal stem cells (MSCs) can differentiate into several lineages during development and also contribute to tissue homeostasis and regeneration, although the requirements for both may be distinct. MSC lineage commitment and progression in differentiation are regulated by members of the transforming growth factor-β (TGF-β) family. This review focuses on the roles of TGF-β family signaling in mesenchymal lineage commitment and differentiation into osteoblasts, chondrocytes, myoblasts, adipocytes, and tenocytes.We summarize the reported findings of cell culture studies, animal models, and interactions with other signaling pathways and highlight how aberrations in TGF-β family signaling can drive human disease by affecting mesenchymal differentiation.
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U2 - 10.1101/cshperspect.a022202
DO - 10.1101/cshperspect.a022202
M3 - Article
C2 - 28507020
AN - SCOPUS:85030423895
SN - 1943-0264
VL - 10
JO - Cold Spring Harbor Perspectives in Biology
JF - Cold Spring Harbor Perspectives in Biology
IS - 5
M1 - a022202
ER -