TGF-β regulation by Emilin1: New links in the etiology of hypertension

Malavika Raman, Melanie H. Cobb

Research output: Contribution to journalShort survey

11 Scopus citations

Abstract

Hypertension is a complex disease influenced by multiple genetic and environmental factors. The TGF-β signaling pathway has a long recognized role in blood pressure homeostasis. In this issue of Cell, Zacchigna et al. (2006) report that the secreted protein Emilin1 is a negative regulator of TGF-β signaling. Emilin1 knockout mice display elevated blood pressure due to increased TGF-β signaling in the vasculature.

Original languageEnglish (US)
Pages (from-to)893-895
Number of pages3
JournalCell
Volume124
Issue number5
DOIs
StatePublished - Mar 10 2006

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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