Hypertension is a complex disease influenced by multiple genetic and environmental factors. The TGF-β signaling pathway has a long recognized role in blood pressure homeostasis. In this issue of Cell, Zacchigna et al. (2006) report that the secreted protein Emilin1 is a negative regulator of TGF-β signaling. Emilin1 knockout mice display elevated blood pressure due to increased TGF-β signaling in the vasculature.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)