TGF-β1 neutralizing antibodies decrease the fibrotic effects of ischemic priapism

O. Sanli, A. Armagan, E. Kandirali, B. Ozerman, I. Ahmedov, S. Solakoglu, A. Nurten, M. Tunç, V. Uysal, A. Kadioglu

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The objective of this study was to evaluate the possible role of transforming growth factor beta 1 (TGF-β1) antibodies (ab) for the prevention of fibrotic effects of priapism in a rat model. In total, 30 adult Sprague-Dawley rats were divided into five groups. Priapism with 6 h (group 1), priapism with 6 h + ab (group 2), priapism with 24 h (group 3), priapism with 24 h + ab (group 4) and control (group 5). Priapism was induced with a vacuum erection device and a rubber band was placed at the base of the erect penis. At 1 h after the initiation of priapism, TGF-β1 antibodies were given intracavernosaly. All rats underwent electrical stimulation of the cavernous nerve after 8 weeks. Intracavernous and systemic blood pressures were measured during the procedure. Rats in group 1 showed significantly higher (intracavemosal pressure (ICP) pressures to cavernous nerve stimulation and had higher ICP/BP ratios when compared to other groups. Similarly, histopathologic examination revealed less fibrosis in group 2, compared with the other groups. Consequently, TGF-β1 antibodies antagonise the fibrotic effects of TGF-β1, especially in cases with duration of priapism less than 6 h.

Original languageEnglish (US)
Pages (from-to)492-497
Number of pages6
JournalInternational Journal of Impotence Research
Volume16
Issue number6
DOIs
StatePublished - Dec 1 2004

Keywords

  • Animal models
  • Priapism of penis and clitoris

ASJC Scopus subject areas

  • Urology

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    Sanli, O., Armagan, A., Kandirali, E., Ozerman, B., Ahmedov, I., Solakoglu, S., Nurten, A., Tunç, M., Uysal, V., & Kadioglu, A. (2004). TGF-β1 neutralizing antibodies decrease the fibrotic effects of ischemic priapism. International Journal of Impotence Research, 16(6), 492-497. https://doi.org/10.1038/sj.ijir.3901261