Abstract
We studied T-BiRD (thalidomide [Thalomid®], clarithromycin [Biaxin®], lenalidomide [Revlimid®] and dexamethasone) in symptomatic, newly diagnosed multiple myeloma. In 28-day cycles, patients received dexamethasone 40 mg/day on days 1, 8, 15, 22, clarithromycin 500 mg twice daily on days 1-28; lenalidomide 25 mg/day on days 1-21; and thalidomide 100 mg/day (50 mg/day on days 1-7 of cycle 1 only) on days 1-28. Twenty-six patients received a median of 6 cycles (range 0-41). Overall response rate (ORR) was 80% for the group and 100% in 11 patients who underwent autologous stem cell transplantation as part of first-line therapy. The 4-year overall survival rate was 74.9%, and the median progression-free survival was 35.6 months. Eight patients discontinued due to regimen toxicity. Grade 3 non hematologic toxicity affected 12 patients (46.2%). T-BiRD is a highly active regimen with potential toxicity limitations. ClinicalTrials.gov
Original language | English (US) |
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Pages (from-to) | 2842-2849 |
Number of pages | 8 |
Journal | Leukemia and Lymphoma |
Volume | 55 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1 2014 |
Keywords
- Clarithromycin
- Dexamethasone
- Lenalidomide
- Newly diagnosed multiple myeloma
- Thalidomide
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research