TH‐C‐224C‐02: MicroRT/microRTP: A Conformal Small Animal Planning and Irradiation System

S. Stojadinovic, A. Hope, M. Vicic, S. Mutic, J. Deasy, J. Cui, D. Khullar, P. Parikh, J. Esthappan, P. Grigsby, D. Low

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: We have developed a novel small animal radiation therapy device (microRT), which integrates multi‐modality imaging, radiation treatment planning, and conformal radiation therapy. In this study, we evaluated the accuracy of the treatment planning and positioning systems of the microRT device. Method and Materials: The microRT system utilizes a clinical 192Ir HDR source collimated via machined tungsten inserts to deliver photon beams at a source to target distances of 1–8cm at four angles (0, 90, 180, and 270). Beams were modeled using Monte Carlo and a parameterized analytic dose engine was created. Radiochromic film (5mm steps) in a solid water phantom was used to evaluate actual delivered doses in multiple planes. Treatment plans using these beams were created by a custom treatment planning system (microRTP) based on imported fiducial‐registered imaging (CT, MR, PET) of animals immobilized in the treatment position. A three‐axis computer‐controlled stage supports and positions animals in the beams according to the microRTP plan. Validation of the positioning system was performed using a phantom and images of phantom and collimator via a kV C‐arm. Results: The analytic dose model agreed with the Monte‐Carlo predicted dose within 5% and 10% outside and inside the 1 mm deep build‐up regions, respectively. Film dosimetry agreed with the analytic model within 10% and also demonstrated an effective field diameter of 8mm at 17mm from the source. The 192Ir line source geometry caused a radial anisotropy of up to 12% at 17 mm depth from the source. The positioning accuracy of the animal support hardware was sub‐millimeter. Conclusions: The microRT system provides conformal radiation therapy based on pre‐treatment imaging and planning for small animal models of cancer and tissue injury. This work supported in part by NIH R21 CA108677 and by a grant from Varian, Inc.

Original languageEnglish (US)
Pages (from-to)2273
Number of pages1
JournalMedical Physics
Volume33
Issue number6
DOIs
StatePublished - 2006

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Radiotherapy
Film Dosimetry
Therapeutics
Equipment and Supplies
Tungsten
Organized Financing
Anisotropy
Photons
Animal Models
Radiation
Water
Wounds and Injuries
Neoplasms

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

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TH‐C‐224C‐02 : MicroRT/microRTP: A Conformal Small Animal Planning and Irradiation System. / Stojadinovic, S.; Hope, A.; Vicic, M.; Mutic, S.; Deasy, J.; Cui, J.; Khullar, D.; Parikh, P.; Esthappan, J.; Grigsby, P.; Low, D.

In: Medical Physics, Vol. 33, No. 6, 2006, p. 2273.

Research output: Contribution to journalArticle

Stojadinovic, S, Hope, A, Vicic, M, Mutic, S, Deasy, J, Cui, J, Khullar, D, Parikh, P, Esthappan, J, Grigsby, P & Low, D 2006, 'TH‐C‐224C‐02: MicroRT/microRTP: A Conformal Small Animal Planning and Irradiation System', Medical Physics, vol. 33, no. 6, pp. 2273. https://doi.org/10.1118/1.2241875
Stojadinovic, S. ; Hope, A. ; Vicic, M. ; Mutic, S. ; Deasy, J. ; Cui, J. ; Khullar, D. ; Parikh, P. ; Esthappan, J. ; Grigsby, P. ; Low, D. / TH‐C‐224C‐02 : MicroRT/microRTP: A Conformal Small Animal Planning and Irradiation System. In: Medical Physics. 2006 ; Vol. 33, No. 6. pp. 2273.
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abstract = "Purpose: We have developed a novel small animal radiation therapy device (microRT), which integrates multi‐modality imaging, radiation treatment planning, and conformal radiation therapy. In this study, we evaluated the accuracy of the treatment planning and positioning systems of the microRT device. Method and Materials: The microRT system utilizes a clinical 192Ir HDR source collimated via machined tungsten inserts to deliver photon beams at a source to target distances of 1–8cm at four angles (0, 90, 180, and 270). Beams were modeled using Monte Carlo and a parameterized analytic dose engine was created. Radiochromic film (5mm steps) in a solid water phantom was used to evaluate actual delivered doses in multiple planes. Treatment plans using these beams were created by a custom treatment planning system (microRTP) based on imported fiducial‐registered imaging (CT, MR, PET) of animals immobilized in the treatment position. A three‐axis computer‐controlled stage supports and positions animals in the beams according to the microRTP plan. Validation of the positioning system was performed using a phantom and images of phantom and collimator via a kV C‐arm. Results: The analytic dose model agreed with the Monte‐Carlo predicted dose within 5{\%} and 10{\%} outside and inside the 1 mm deep build‐up regions, respectively. Film dosimetry agreed with the analytic model within 10{\%} and also demonstrated an effective field diameter of 8mm at 17mm from the source. The 192Ir line source geometry caused a radial anisotropy of up to 12{\%} at 17 mm depth from the source. The positioning accuracy of the animal support hardware was sub‐millimeter. Conclusions: The microRT system provides conformal radiation therapy based on pre‐treatment imaging and planning for small animal models of cancer and tissue injury. This work supported in part by NIH R21 CA108677 and by a grant from Varian, Inc.",
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AU - Stojadinovic, S.

AU - Hope, A.

AU - Vicic, M.

AU - Mutic, S.

AU - Deasy, J.

AU - Cui, J.

AU - Khullar, D.

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AU - Grigsby, P.

AU - Low, D.

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