@article{e13580023a644216b1c0dbc2aebe014b,
title = "The adipocyte-secreted protein Acrp30 enhances hepatic insulin action",
abstract = "Acrp30 is a circulating protein synthesized in adipose tissue. A single injection in mice of purified recombinant Acrp30 leads to a 2-3-fold elevation in circulating Acrp30 levels, which triggers a transient decrease in basal glucose levels. Similar treatment in ob/ob, NOD (non-obese diabetic) or streptozotocin-treated mice transiently abolishes hyperglycemia. This effect on glucose is not associated with an increase in insulin levels. Moreover, in isolated hepatocytes, Acrp30 increases the ability of sub-physiological levels of insulin to suppress glucose production. We thus propose that Acrp30 is a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism.",
author = "Berg, {Anders H.} and Combs, {Terry P.} and Xueliang Du and Michael Brownlee and Scherer, {Philipp E.}",
note = "Funding Information: Acknowledgments We thank L. Rossetti, M. Charron and D. Stein for helpful discussions; D. Harrison and S. Klebanov for control and food-restricted serum samples; S. Nathenson and T. DiLorenzo for providing NOD mice for experiments; D. Neufeld for his help in isolating rat primary hepatocytes; and F. Mancia and A. Nemes for vector pFM1. This work was supported by the Training Program in Cellular & Molecular Biology & Genetics (T32-GM07491 to A.H.B.), the Hormones/Membrane Interactions Training Grant (NIH-T32 DK 07513-15 to T.C.), grants from the American Diabetes Association (to P.E.S.) and a NIH grant from the NIDDK (1R01-DK55758 to P.E.S.). Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",
year = "2001",
doi = "10.1038/90992",
language = "English (US)",
volume = "7",
pages = "947--953",
journal = "Nature medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",
number = "8",
}