The adipokine SAA3 is induced by interleukin-1β in mouse adipocytes

Grit Sommer, Sebastian Weise, Susan Kralisch, Philipp E. Scherer, Ulrike Lössner, Matthias Blüher, Michael Stumvoll, Mathias Fasshauer

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Serum amyloid A (SAA) 3 has been characterized as an inflammatory adipocyte-secreted acute-phase reactant. In the current study, regulation of SAA3 by the proinflammatory and insulin resistance-inducing cytokine interleukin (IL)-1β was determined in 3T3-L1 and brown adipocytes. Interestingly, SAA3 mRNA and protein synthesis were dramatically increased by IL-1β in a time-dependent fashion with maximal induction after 24 h. Furthermore, IL-1β significantly induced SAA3 mRNA expression dose-dependently with maximal 36.4-fold upregulation seen at 2 ng/ml effector. Moreover, IL-1β-induced SAA3 expression was mediated by nuclear factor-κB and janus kinase 2. Taken together, our data show a potent upregulation of SAA3 by IL-1β.

Original languageEnglish (US)
Pages (from-to)2241-2247
Number of pages7
JournalJournal of Cellular Biochemistry
Volume104
Issue number6
DOIs
StatePublished - Aug 15 2008

Keywords

  • 3T3-L1 adipocyte
  • Adipokine
  • Interleukin-1β
  • Serum amyloid A3

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Sommer, G., Weise, S., Kralisch, S., Scherer, P. E., Lössner, U., Blüher, M., Stumvoll, M., & Fasshauer, M. (2008). The adipokine SAA3 is induced by interleukin-1β in mouse adipocytes. Journal of Cellular Biochemistry, 104(6), 2241-2247. https://doi.org/10.1002/jcb.21782