The adipokine/ceramide axis: Key aspects of insulin sensitization

Jonathan Y. Xia, Thomas S. Morley, Philipp E. Scherer

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Until recently, sphingolipid physiology was primarily the domain of oncologists and immunologists. However, mounting evidence implicates ceramides and their derivatives in various aspects of metabolism via directly impacting the insulin receptor as well as modulating cell survival and proliferation. More recent observations suggest a strong link between a number of adipokines and ceramide catabolism. Here, we aim to briefly review the available data on the established metabolic effects of sphingolipids in various cell types and will discuss how adipokines exert a critical influence on the steady state levels of these lipid mediators.

Original languageEnglish (US)
Pages (from-to)130-139
Number of pages10
JournalBiochimie
Volume96
Issue number1
DOIs
StatePublished - Jan 2014

Fingerprint

Sphingolipids
Adipokines
Ceramides
Insulin
Insulin Receptor
Physiology
Mountings
Metabolism
Cell Survival
Cells
Cell Proliferation
Derivatives
Lipids
Oncologists

Keywords

  • Ceramide target tissues
  • Ceramides
  • Insulin sensitivity
  • Plasma ceramide levels
  • Sphingolipids

ASJC Scopus subject areas

  • Biochemistry

Cite this

The adipokine/ceramide axis : Key aspects of insulin sensitization. / Xia, Jonathan Y.; Morley, Thomas S.; Scherer, Philipp E.

In: Biochimie, Vol. 96, No. 1, 01.2014, p. 130-139.

Research output: Contribution to journalArticle

Xia, Jonathan Y. ; Morley, Thomas S. ; Scherer, Philipp E. / The adipokine/ceramide axis : Key aspects of insulin sensitization. In: Biochimie. 2014 ; Vol. 96, No. 1. pp. 130-139.
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