The aging kidney

Xin J. Zhou, Dinesh Rakheja, Xueqing Yu, Ramesh Saxena, Nosratola D. Vaziri, Fred G. Silva

Research output: Contribution to journalReview article

236 Scopus citations

Abstract

Renal aging, by itself, is associated with alterations in renal morphology and a decline in renal function, which is accelerated and/or accentuated by diseases such as diabetes mellitus and hypertension. The aging-related renal insufficiency has important implications with regards to body homeostasis, drug toxicity, and renal transplantation. An understanding of renal aging and its distinction from renal insufficiency secondary to diseases is essential for individualized care of the elderly. Toward this end, investigations are underway to elucidate the molecular mechanisms of renal aging. This review summarizes the structural and functional changes of the aging kidney and highlights the advances made in our understanding of the renal aging process.

Original languageEnglish (US)
Pages (from-to)710-720
Number of pages11
JournalKidney international
Volume74
Issue number6
DOIs
StatePublished - Sep 1 2008

Keywords

  • Kidney transplantation
  • Molecular mechanism
  • Oxidative stress
  • Pathology
  • Pathophysiology
  • Senescence

ASJC Scopus subject areas

  • Nephrology

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    Zhou, X. J., Rakheja, D., Yu, X., Saxena, R., Vaziri, N. D., & Silva, F. G. (2008). The aging kidney. Kidney international, 74(6), 710-720. https://doi.org/10.1038/ki.2008.319