The Albert Lasker Medical Awards. G proteins and regulation of adenylyl cyclase.

A. G. Gilman

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

The cellular plasma membrane contains highly specialized systems for integration, amplification, and transduction of information that presents itself in the form of extracellular hormones, neurotransmitters, other regulatory molecules, and physical stimuli. A major mechanism for processing this information involves the sequential interactions of three membrane-bound proteins. Receptors for many extracellular regulators bind these molecules and interact with one or more of a family of guanine nucleotide-binding regulatory proteins (G proteins). Conformational alteration of the G protein permits exchange of tightly bound guanosine diphosphate (an inactive ligand) for guanosine triphosphate (the activating ligand). The guanosine triphosphate-bound G protein in turn interacts with intracellular effector molecules, such as adenylyl cyclase, and controls their functions.

Original languageEnglish (US)
Pages (from-to)1819-1825
Number of pages7
JournalJournal of the American Medical Association
Volume262
Issue number13
StatePublished - Oct 6 1989

Fingerprint

GTP-Binding Proteins
Adenylyl Cyclases
Carrier Proteins
Guanosine Triphosphate
Ligands
Systems Integration
Guanosine
Diphosphates
Automatic Data Processing
Neurotransmitter Agents
Membrane Proteins
Cell Membrane
Hormones

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The Albert Lasker Medical Awards. G proteins and regulation of adenylyl cyclase. / Gilman, A. G.

In: Journal of the American Medical Association, Vol. 262, No. 13, 06.10.1989, p. 1819-1825.

Research output: Contribution to journalArticle

@article{9fc08e61558f4da594cf7e7dbe331d5a,
title = "The Albert Lasker Medical Awards. G proteins and regulation of adenylyl cyclase.",
abstract = "The cellular plasma membrane contains highly specialized systems for integration, amplification, and transduction of information that presents itself in the form of extracellular hormones, neurotransmitters, other regulatory molecules, and physical stimuli. A major mechanism for processing this information involves the sequential interactions of three membrane-bound proteins. Receptors for many extracellular regulators bind these molecules and interact with one or more of a family of guanine nucleotide-binding regulatory proteins (G proteins). Conformational alteration of the G protein permits exchange of tightly bound guanosine diphosphate (an inactive ligand) for guanosine triphosphate (the activating ligand). The guanosine triphosphate-bound G protein in turn interacts with intracellular effector molecules, such as adenylyl cyclase, and controls their functions.",
author = "Gilman, {A. G.}",
year = "1989",
month = "10",
day = "6",
language = "English (US)",
volume = "262",
pages = "1819--1825",
journal = "JAMA - Journal of the American Medical Association",
issn = "0098-7484",
publisher = "American Medical Association",
number = "13",

}

TY - JOUR

T1 - The Albert Lasker Medical Awards. G proteins and regulation of adenylyl cyclase.

AU - Gilman, A. G.

PY - 1989/10/6

Y1 - 1989/10/6

N2 - The cellular plasma membrane contains highly specialized systems for integration, amplification, and transduction of information that presents itself in the form of extracellular hormones, neurotransmitters, other regulatory molecules, and physical stimuli. A major mechanism for processing this information involves the sequential interactions of three membrane-bound proteins. Receptors for many extracellular regulators bind these molecules and interact with one or more of a family of guanine nucleotide-binding regulatory proteins (G proteins). Conformational alteration of the G protein permits exchange of tightly bound guanosine diphosphate (an inactive ligand) for guanosine triphosphate (the activating ligand). The guanosine triphosphate-bound G protein in turn interacts with intracellular effector molecules, such as adenylyl cyclase, and controls their functions.

AB - The cellular plasma membrane contains highly specialized systems for integration, amplification, and transduction of information that presents itself in the form of extracellular hormones, neurotransmitters, other regulatory molecules, and physical stimuli. A major mechanism for processing this information involves the sequential interactions of three membrane-bound proteins. Receptors for many extracellular regulators bind these molecules and interact with one or more of a family of guanine nucleotide-binding regulatory proteins (G proteins). Conformational alteration of the G protein permits exchange of tightly bound guanosine diphosphate (an inactive ligand) for guanosine triphosphate (the activating ligand). The guanosine triphosphate-bound G protein in turn interacts with intracellular effector molecules, such as adenylyl cyclase, and controls their functions.

UR - http://www.scopus.com/inward/record.url?scp=0024417344&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024417344&partnerID=8YFLogxK

M3 - Article

VL - 262

SP - 1819

EP - 1825

JO - JAMA - Journal of the American Medical Association

JF - JAMA - Journal of the American Medical Association

SN - 0098-7484

IS - 13

ER -