The alchemy of tendon repair: A primer for the (S)mad scientist

Dwight A. Towler, Richard H. Gelberman

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

During vertebrate development, mesenchymal progenitors capable of forming bone, cartilage, muscle, fat, or tendon arise from either neural crest or somitic mesoderm. Transcriptional programs that specify mesenchymal cell fates are initiated and modified by paracrine cues provided by TGF-β superfamily members and mediated in part via the regulated assembly of Smad-containing multiprotein transcription factor complexes. In this issue of the JCI, Hoffmann and colleagues have identified that Smad8 activation drives tendon formation from C3H10T1/2 cells, a murine cell line that recapitulates many features of normal multipotent mesenchymal cells (see the related article beginning on page 940). Cells programmed to the tenocyte cell fate in vitro formed tenogenic grafts in vivo. These results add to the accumulating evidence that proliferating, multipotent mesenchymal progenitor cells can be programmed to yield multiple cell types - e.g., osteoblasts, myocytes, chondrocytes, and tenocytes - that may be useful in cell-based therapeutic approaches to musculoskeletal diseases.

Original languageEnglish (US)
Pages (from-to)863-866
Number of pages4
JournalJournal of Clinical Investigation
Volume116
Issue number4
DOIs
StatePublished - Apr 1 2006

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Alchemy
Tendons
Musculoskeletal Diseases
Neural Crest
Mesoderm
Chondrocytes
Osteoblasts
Mesenchymal Stromal Cells
Muscle Cells
Cartilage
Cues
Vertebrates
Transcription Factors
Fats
Transplants
Bone and Bones
Cell Line
Muscles

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The alchemy of tendon repair : A primer for the (S)mad scientist. / Towler, Dwight A.; Gelberman, Richard H.

In: Journal of Clinical Investigation, Vol. 116, No. 4, 01.04.2006, p. 863-866.

Research output: Contribution to journalReview article

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