The amide protons of an ytterbium(III) dota tetraamide complex act as efficient antennae for transfer of magnetization to bulk water

Shanrong Zhang, Lydie Michaudet, Shawn Burgess, A. Dean Sherry

Research output: Contribution to journalArticle

85 Scopus citations

Abstract

Contrast agent for magnetic resonance imaging: The exchangeable amide protons in the Yb3+ complex of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetamide (see crystal structure) act as efficient antennae for transfer of saturated spins to bulk water. Saturation of all eight protons in a 5 mm solution of this complex results in a 38% decrease in the signal intensity of bulk water. The compound thus has promise as a magnetization-transfer contrast agent for magnetic resonance imaging.

Original languageEnglish (US)
Pages (from-to)1919-1921
Number of pages3
JournalAngewandte Chemie - International Edition
Volume41
Issue number11
DOIs
StatePublished - Jun 3 2002

Keywords

  • Amides
  • Imaging agents
  • Lanthanides
  • Macrocycles
  • NMR spectroscopy

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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