Contrast agent for magnetic resonance imaging: The exchangeable amide protons in the Yb3+ complex of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetamide (see crystal structure) act as efficient antennae for transfer of saturated spins to bulk water. Saturation of all eight protons in a 5 mm solution of this complex results in a 38% decrease in the signal intensity of bulk water. The compound thus has promise as a magnetization-transfer contrast agent for magnetic resonance imaging.
|Original language||English (US)|
|Number of pages||3|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - Jun 3 2002|
- Imaging agents
- NMR spectroscopy
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