Abstract
(Chemical Equation Presented) From the ocean: Ammosamides A (1) and B (2) were isolated from a marine-derived Streptomyces species collected in the Bahamas. The structures of these chlorinated tricyclic pyrroloquinoline alkaloids were solved using X-ray crystallographic techniques. Ammosamide A (1) was shown to contain an unusual thio-γ-lactam ring. Both metabolites show specific nanomolar cytotoxicity against selected cancer cell lines.
Original language | English (US) |
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Pages (from-to) | 725-727 |
Number of pages | 3 |
Journal | Angewandte Chemie - International Edition |
Volume | 48 |
Issue number | 4 |
DOIs | |
State | Published - Jan 12 2009 |
Keywords
- Actinomycetes
- Alkaloids
- Natural products
- Quinolines
- Thiolactams
ASJC Scopus subject areas
- Catalysis
- General Chemistry