The Angiopoietin-Tie2 Pathway in Critical Illness

Kelsey D. Sack, John A. Kellum, Samir M. Parikh

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Lethal features of sepsis and acute respiratory distress syndrome (ARDS) relate to the health of small blood vessels. For example, alveolar infiltration with proteinaceous fluid is often driven by breach of the microvascular barrier. Spontaneous thrombus formation within inflamed microvessels exacerbates organ ischemia, and in its final stages, erupts into overt disseminated intravascular coagulation. Disruption of an endothelial signaling axis, the Angiopoietin-Tie2 pathway, may mediate the abrupt transition from microvascular integrity to pathologic disruption. This review summarizes preclinical and clinical results that implicate the Tie2 pathway as a promising target to restore microvascular health in sepsis and ARDS.

Original languageEnglish (US)
Pages (from-to)201-216
Number of pages16
JournalCritical Care Clinics
Volume36
Issue number2
DOIs
StatePublished - Apr 2020
Externally publishedYes

Keywords

  • ARDS
  • Angiopoietin
  • Coagulation
  • Sepsis
  • Tie2
  • VE-PTP
  • Vascular leakage

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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