Abstract
Many proteins rely on stable, noncovalent interactions with other macromolecules to perform their function. The identification of a repeated sequence motif, the ANK repeat, in diverse proteins whose common function involves binding to other proteins indicates one way nature may achieve a wide range of protein-protein interactions. In this article, we describe evidence that these ANK repeats are involved in the specific recognition of proteins and possibly DNA, and present a model for the folding of the motif.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 127-129 |
| Number of pages | 3 |
| Journal | Trends in Cell Biology |
| Volume | 2 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1992 |
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ASJC Scopus subject areas
- Cell Biology
Cite this
The ANK repeat : a ubiquitous motif involved in macromolecular recognition. / Michaely, Peter; Bennett, Vann.
In: Trends in Cell Biology, Vol. 2, No. 5, 1992, p. 127-129.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The ANK repeat
T2 - a ubiquitous motif involved in macromolecular recognition
AU - Michaely, Peter
AU - Bennett, Vann
PY - 1992
Y1 - 1992
N2 - Many proteins rely on stable, noncovalent interactions with other macromolecules to perform their function. The identification of a repeated sequence motif, the ANK repeat, in diverse proteins whose common function involves binding to other proteins indicates one way nature may achieve a wide range of protein-protein interactions. In this article, we describe evidence that these ANK repeats are involved in the specific recognition of proteins and possibly DNA, and present a model for the folding of the motif.
AB - Many proteins rely on stable, noncovalent interactions with other macromolecules to perform their function. The identification of a repeated sequence motif, the ANK repeat, in diverse proteins whose common function involves binding to other proteins indicates one way nature may achieve a wide range of protein-protein interactions. In this article, we describe evidence that these ANK repeats are involved in the specific recognition of proteins and possibly DNA, and present a model for the folding of the motif.
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UR - http://www.scopus.com/inward/citedby.url?scp=0026607234&partnerID=8YFLogxK
U2 - 10.1016/0962-8924(92)90084-Z
DO - 10.1016/0962-8924(92)90084-Z
M3 - Article
C2 - 14731966
AN - SCOPUS:0026607234
VL - 2
SP - 127
EP - 129
JO - Trends in Cell Biology
JF - Trends in Cell Biology
SN - 0962-8924
IS - 5
ER -