The ANK repeat: a ubiquitous motif involved in macromolecular recognition

Peter Michaely, Vann Bennett

Research output: Contribution to journalArticle

168 Scopus citations

Abstract

Many proteins rely on stable, noncovalent interactions with other macromolecules to perform their function. The identification of a repeated sequence motif, the ANK repeat, in diverse proteins whose common function involves binding to other proteins indicates one way nature may achieve a wide range of protein-protein interactions. In this article, we describe evidence that these ANK repeats are involved in the specific recognition of proteins and possibly DNA, and present a model for the folding of the motif.

Original languageEnglish (US)
Pages (from-to)127-129
Number of pages3
JournalTrends in Cell Biology
Volume2
Issue number5
DOIs
StatePublished - May 1992

ASJC Scopus subject areas

  • Cell Biology

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