The apoE receptor apoER2 is involved in the maintenance of efficient synaptic plasticity

Caroline Petit-Turcotte, Nicole Aumont, Uwe Beffert, Doris Dea, Joachim Herz, Judes Poirier

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

ApoER2 is one of the major receptors for ApoE in the brain, and has been shown to be involved not only in lipoprotein endocytosis, as other members of the LDL receptor family of receptors, but also in various cellular functions such as signalling and cellular guidance. By using a model of synaptic plasticity in mice lacking none, one or two alleles of the apoER2 gene, we investigated the implication of such a receptor deficiency on the remodelling process. Our results indicate that animals lacking apoER2 express higher levels of brain APP, as well as both key amyloid peptides, while apoE levels are slightly lower. Following entorhinal cortex lesioning, apoE levels increase in the deafferented hippocampus, while a delay in the increase of APP was observed. Hippocampal amyloid levels are also increased in response to the lesion, and highly potentiated by the complete absence of apoER2 gene. The results suggest a significant role for apoER2 in signalling various proteins in response to massive deafferentation and may participate in maintaining efficient synaptic plasticity and dendritic remodelling.

Original languageEnglish (US)
Pages (from-to)195-206
Number of pages12
JournalNeurobiology of Aging
Volume26
Issue number2
DOIs
StatePublished - Feb 1 2005

Keywords

  • AD
  • APP
  • Alzheimer's disease
  • Apolipoprotein E receptor
  • ECL
  • Synaptic plasticity
  • amyloid precursor protein
  • amyloid-beta peptide
  • apoE
  • apoE receptor type 2
  • apoER2
  • apolipoprotein E
  • entorhinal cortex lesioning

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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