The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease

Courtney Lane-Donovan, Joachim Herz

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


The LDL receptor (LDLR) family has long been studied for its role in cholesterol transport and metabolism; however, the identification of ApoE4, an LDLR ligand, as a genetic risk factor for late-onset Alzheimer’s disease has focused attention on the role this receptor family plays in the CNS. Surprisingly, it was discovered that two LDLR family members, ApoE receptor 2 (Apoer2) and VLDL receptor (Vldlr), play key roles in brain development and adult synaptic plasticity, primarily by mediating Reelin signaling. This review focuses on Apoer2 and Vldlr signaling in the CNS and its role in human disease.—Lane-Donovan, C., and J. Herz. The A oE rece tors Vldlr and A oer2 in central nervous s stem function and disease.

Original languageEnglish (US)
Pages (from-to)1036-1043
Number of pages8
JournalJournal of lipid research
Issue number6
StatePublished - Jun 2017


  • Alzheimer’s disease
  • Apolipoprotein E
  • Apolipoprotein E receptor 2
  • Cell signaling
  • Endocytosis
  • Lipoprotein receptors
  • Neurons
  • Supplementary key words apolipoproteins
  • Very low density lipoprotein receptor

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Cell Biology


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