The Argonaute family: Tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis

Michelle A. Carmell, Zhenyu Xuan, Michael Q. Zhang, Gregory J. Hannon

Research output: Contribution to journalReview articlepeer-review

656 Scopus citations

Abstract

In conclusion, Argonaute proteins comprise a highly conserved protein family that is involved in a variety of RNA silencing phenomena in a diverse set of organisms. Perhaps through RNAi-related pathways or possibly also through distinct mechanisms, Argonaute family members have a variety of biological roles. These include regulation of development and determination of stem-cell character. Through an ever-advancing understanding of the biochemistry and genetics of the Argonaute family, we may ultimately reveal the reach of these pathways into the basic biological mechanisms that underlie a variety of human diseases.

Original languageEnglish (US)
Pages (from-to)2733-2742
Number of pages10
JournalGenes and Development
Volume16
Issue number21
DOIs
StatePublished - Nov 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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