The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells

M. Carmen Lafita-Navarro; Min Kim; Nofit Borenstein-Auerbach; Niranjan Venkateswaran; Yi Heng Hao; Roshni Ray; Thomas Brabletz; Pier Paolo Scaglioni; Jerry W. Shay; Maralice Conacci-Sorrell

doi:10.1101/GAD.313007.118

The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells

M. Carmen Lafita-Navarro, Min Kim, Nofit Borenstein-Auerbach, Niranjan Venkateswaran, Yi Heng Hao, Roshni Ray, Thomas Brabletz, Pier Paolo Scaglioni, Jerry W. Shay, Maralice Conacci-Sorrell

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

MYC enhances protein synthesis by regulating genes involved in ribosome biogenesis and protein translation. Here, we show that MYC-induced protein translation is mediated by the transcription factor aryl hydrocarbon receptor (AHR), which is induced by MYC in colonic cells. AHR promotes protein synthesis by activating the transcription of genes required for ribosome biogenesis and protein translation, including OGFOD1 and NOLC1. Using surface sensing of translation (SUnSET) to measure global protein translation, we found that silencing AHR or its targets diminishes protein synthesis. Therefore, targeting AHR or its downstream pathways could provide a novel approach to limit biomass production in MYC-driven tumors.

Original language	English (US)
Pages (from-to)	1303-1308
Number of pages	6
Journal	Genes and Development
Volume	32
Issue number	19-20
DOIs	https://doi.org/10.1101/GAD.313007.118
State	Published - 2018

Keywords

AHR
Aryl hydrocarbon receptor
Cancer
Myc
Nucleolus
Ribosome biogenesis
Transcription
Translation]

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1101/GAD.313007.118

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title = "The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells",

abstract = "MYC enhances protein synthesis by regulating genes involved in ribosome biogenesis and protein translation. Here, we show that MYC-induced protein translation is mediated by the transcription factor aryl hydrocarbon receptor (AHR), which is induced by MYC in colonic cells. AHR promotes protein synthesis by activating the transcription of genes required for ribosome biogenesis and protein translation, including OGFOD1 and NOLC1. Using surface sensing of translation (SUnSET) to measure global protein translation, we found that silencing AHR or its targets diminishes protein synthesis. Therefore, targeting AHR or its downstream pathways could provide a novel approach to limit biomass production in MYC-driven tumors.",

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doi = "10.1101/GAD.313007.118",

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AU - Lafita-Navarro, M. Carmen

AU - Kim, Min

AU - Borenstein-Auerbach, Nofit

AU - Venkateswaran, Niranjan

AU - Hao, Yi Heng

AU - Ray, Roshni

AU - Brabletz, Thomas

AU - Scaglioni, Pier Paolo

AU - Shay, Jerry W.

AU - Conacci-Sorrell, Maralice

PY - 2018

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AB - MYC enhances protein synthesis by regulating genes involved in ribosome biogenesis and protein translation. Here, we show that MYC-induced protein translation is mediated by the transcription factor aryl hydrocarbon receptor (AHR), which is induced by MYC in colonic cells. AHR promotes protein synthesis by activating the transcription of genes required for ribosome biogenesis and protein translation, including OGFOD1 and NOLC1. Using surface sensing of translation (SUnSET) to measure global protein translation, we found that silencing AHR or its targets diminishes protein synthesis. Therefore, targeting AHR or its downstream pathways could provide a novel approach to limit biomass production in MYC-driven tumors.

KW - AHR

KW - Aryl hydrocarbon receptor

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KW - Myc

KW - Nucleolus

KW - Ribosome biogenesis

KW - Transcription

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The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells

Abstract

Keywords

ASJC Scopus subject areas

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