The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells

M. Carmen Lafita-Navarro, Min Kim, Nofit Borenstein-Auerbach, Niranjan Venkateswaran, Yi Heng Hao, Roshni Ray, Thomas Brabletz, Pier Paolo Scaglioni, Jerry W. Shay, Maralice Conacci-Sorrell

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

MYC enhances protein synthesis by regulating genes involved in ribosome biogenesis and protein translation. Here, we show that MYC-induced protein translation is mediated by the transcription factor aryl hydrocarbon receptor (AHR), which is induced by MYC in colonic cells. AHR promotes protein synthesis by activating the transcription of genes required for ribosome biogenesis and protein translation, including OGFOD1 and NOLC1. Using surface sensing of translation (SUnSET) to measure global protein translation, we found that silencing AHR or its targets diminishes protein synthesis. Therefore, targeting AHR or its downstream pathways could provide a novel approach to limit biomass production in MYC-driven tumors.

Original languageEnglish (US)
Pages (from-to)1303-1308
Number of pages6
JournalGenes & development
Volume32
Issue number19-20
DOIs
StatePublished - Oct 1 2018

Fingerprint

Aryl Hydrocarbon Receptors
Protein Biosynthesis
Nuclear Proteins
Ribosomes
Proteins
Biomass
Genes
Transcription Factors
Neoplasms

Keywords

  • AHR
  • aryl hydrocarbon receptor
  • cancer
  • Myc
  • nucleolus
  • ribosome biogenesis
  • transcription
  • translation

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Lafita-Navarro, M. C., Kim, M., Borenstein-Auerbach, N., Venkateswaran, N., Hao, Y. H., Ray, R., ... Conacci-Sorrell, M. (2018). The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells. Genes & development, 32(19-20), 1303-1308. https://doi.org/10.1101/gad.313007.118

The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells. / Lafita-Navarro, M. Carmen; Kim, Min; Borenstein-Auerbach, Nofit; Venkateswaran, Niranjan; Hao, Yi Heng; Ray, Roshni; Brabletz, Thomas; Scaglioni, Pier Paolo; Shay, Jerry W.; Conacci-Sorrell, Maralice.

In: Genes & development, Vol. 32, No. 19-20, 01.10.2018, p. 1303-1308.

Research output: Contribution to journalArticle

Lafita-Navarro, MC, Kim, M, Borenstein-Auerbach, N, Venkateswaran, N, Hao, YH, Ray, R, Brabletz, T, Scaglioni, PP, Shay, JW & Conacci-Sorrell, M 2018, 'The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells', Genes & development, vol. 32, no. 19-20, pp. 1303-1308. https://doi.org/10.1101/gad.313007.118
Lafita-Navarro MC, Kim M, Borenstein-Auerbach N, Venkateswaran N, Hao YH, Ray R et al. The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells. Genes & development. 2018 Oct 1;32(19-20):1303-1308. https://doi.org/10.1101/gad.313007.118
Lafita-Navarro, M. Carmen ; Kim, Min ; Borenstein-Auerbach, Nofit ; Venkateswaran, Niranjan ; Hao, Yi Heng ; Ray, Roshni ; Brabletz, Thomas ; Scaglioni, Pier Paolo ; Shay, Jerry W. ; Conacci-Sorrell, Maralice. / The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells. In: Genes & development. 2018 ; Vol. 32, No. 19-20. pp. 1303-1308.
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