The Association Between Major Depressive Disorder and Outcomes in Older Veterans Hospitalized With Pneumonia

Ami L. DeWaters, Matthieu Chansard, Antonio Anzueto, Mary Jo Pugh, Eric M. Mortensen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Major depressive disorder ("depression") has been identified as an independent risk factor for mortality for many comorbid conditions, including heart failure, cancer and stroke. Major depressive disorder has also been linked to immune suppression by generating a chronic inflammatory state. However, the association between major depression and pneumonia has not been examined. The aim of this study was to examine the association between depression and outcomes, including mortality and intensive care unit admission, in Veterans hospitalized with pneumonia. Materials and Methods: We conducted a retrospective national study using administrative data of patients hospitalized at any Veterans Administration acute care hospital. We included patients ≥65 years old hospitalized with pneumonia from 2002-2012. Depressed patients were further analyzed based on whether they were receiving medications to treat depression. We used generalized linear mixed effect models to examine the association of depression with the outcomes of interest after controlling for potential confounders. Results: Patients with depression had a significantly higher 90-day mortality (odds ratio 1.12, 95% confidence interval 1.07-1.17) compared to patients without depression. Patients with untreated depression had a significantly higher 30-day (1.11, 1.04-1.20) and 90-day (1.20, 1.13-1.28) mortality, as well as significantly higher intensive care unit admission rates (1.12, 1.03-1.21), compared to patients with treated depression. Conclusion: For older veterans hospitalized with pneumonia, a concurrent diagnosis of major depressive disorder, and especially untreated depression, was associated with higher mortality. This highlights that untreated major depressive disorder is an independent risk factor for mortality for patients with pneumonia.

Original languageEnglish (US)
JournalAmerican Journal of the Medical Sciences
DOIs
StateAccepted/In press - Jan 1 2017

Fingerprint

Major Depressive Disorder
Veterans
Pneumonia
Depression
Mortality
Intensive Care Units
United States Department of Veterans Affairs
Heart Neoplasms
Heart Failure
Retrospective Studies
Stroke
Odds Ratio
Confidence Intervals

Keywords

  • Major depressive disorder
  • Mortality
  • Pneumonia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The Association Between Major Depressive Disorder and Outcomes in Older Veterans Hospitalized With Pneumonia. / DeWaters, Ami L.; Chansard, Matthieu; Anzueto, Antonio; Pugh, Mary Jo; Mortensen, Eric M.

In: American Journal of the Medical Sciences, 01.01.2017.

Research output: Contribution to journalArticle

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