Abstract

Background: Caspase-3, an apoptosis protease, is expressed in atherosclerotic plaques. We examined the relationship between plasma caspase-3 levels, aortic compliance, and atherosclerosis. Methods: Caspase-3 was measured in 3,221 subjects from the Dallas Heart Study. Electron beam computed tomography measures of coronary calcium (CAC) (n = 2,404) and magnetic resonance imaging (MRI) measures of abdominal aortic wall thickness (AWT) (n = 2,208) and aortic compliance (AC) (n = 2,328) were obtained. Multivariate analyses were performed, adjusting for age, sex, ethnicity, body mass index (BMI), traditional cardiovascular risk factors, and cardiac medications. Results: In univariable analysis, caspase-3 associated with CAC (P < 0.0001), AWT (P = 0.002), and AC (P < 0.0001). After multivariable adjustment, 4th quartile caspase-3 (compared to 1st quartile) was significantly associated with CAC (P = 0.004), AWT (P = 0.02), and AC (P < 0.0001) with similar findings for caspase-3 as a continuous variable. Conclusions: Caspase-3 independently associates with CAC, AWT, and AC, suggesting a link between apoptosis and atherosclerosis.

Original languageEnglish (US)
Pages (from-to)1281-1289
Number of pages9
JournalApoptosis
Volume13
Issue number10
DOIs
StatePublished - Oct 2008

Fingerprint

Caspase 3
Blood Vessels
Atherosclerosis
Plasmas
Compliance
Calcium
Electron beam computed tomography
Apoptosis
X Ray Computed Tomography
Abdominal Wall
Atherosclerotic Plaques
Magnetic resonance
Body Mass Index
Peptide Hydrolases
Multivariate Analysis
Magnetic Resonance Imaging
Imaging techniques

Keywords

  • Apoptosis
  • Atherosclerosis
  • Biological markers
  • Human
  • Magnetic resonance imaging
  • Tomography
  • X-ray computed

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

Cite this

@article{fd75cbcdc69041649d982f19d9565a40,
title = "The association between plasma caspase-3, atherosclerosis, and vascular function in the Dallas Heart Study",
abstract = "Background: Caspase-3, an apoptosis protease, is expressed in atherosclerotic plaques. We examined the relationship between plasma caspase-3 levels, aortic compliance, and atherosclerosis. Methods: Caspase-3 was measured in 3,221 subjects from the Dallas Heart Study. Electron beam computed tomography measures of coronary calcium (CAC) (n = 2,404) and magnetic resonance imaging (MRI) measures of abdominal aortic wall thickness (AWT) (n = 2,208) and aortic compliance (AC) (n = 2,328) were obtained. Multivariate analyses were performed, adjusting for age, sex, ethnicity, body mass index (BMI), traditional cardiovascular risk factors, and cardiac medications. Results: In univariable analysis, caspase-3 associated with CAC (P < 0.0001), AWT (P = 0.002), and AC (P < 0.0001). After multivariable adjustment, 4th quartile caspase-3 (compared to 1st quartile) was significantly associated with CAC (P = 0.004), AWT (P = 0.02), and AC (P < 0.0001) with similar findings for caspase-3 as a continuous variable. Conclusions: Caspase-3 independently associates with CAC, AWT, and AC, suggesting a link between apoptosis and atherosclerosis.",
keywords = "Apoptosis, Atherosclerosis, Biological markers, Human, Magnetic resonance imaging, Tomography, X-ray computed",
author = "Matulevicius, {Susan A} and Rohatgi, {Anand K} and Amit Khera and Das, {Sandeep R} and Andrew Owens and Ayers, {Colby R.} and Timaran, {Carlos H} and Rosero, {Eric B} and Drazner, {Mark H} and Peshock, {Ronald M} and {de Lemos}, {James A}",
year = "2008",
month = "10",
doi = "10.1007/s10495-008-0254-1",
language = "English (US)",
volume = "13",
pages = "1281--1289",
journal = "Apoptosis : an international journal on programmed cell death",
issn = "1360-8185",
publisher = "Springer Netherlands",
number = "10",

}

TY - JOUR

T1 - The association between plasma caspase-3, atherosclerosis, and vascular function in the Dallas Heart Study

AU - Matulevicius, Susan A

AU - Rohatgi, Anand K

AU - Khera, Amit

AU - Das, Sandeep R

AU - Owens, Andrew

AU - Ayers, Colby R.

AU - Timaran, Carlos H

AU - Rosero, Eric B

AU - Drazner, Mark H

AU - Peshock, Ronald M

AU - de Lemos, James A

PY - 2008/10

Y1 - 2008/10

N2 - Background: Caspase-3, an apoptosis protease, is expressed in atherosclerotic plaques. We examined the relationship between plasma caspase-3 levels, aortic compliance, and atherosclerosis. Methods: Caspase-3 was measured in 3,221 subjects from the Dallas Heart Study. Electron beam computed tomography measures of coronary calcium (CAC) (n = 2,404) and magnetic resonance imaging (MRI) measures of abdominal aortic wall thickness (AWT) (n = 2,208) and aortic compliance (AC) (n = 2,328) were obtained. Multivariate analyses were performed, adjusting for age, sex, ethnicity, body mass index (BMI), traditional cardiovascular risk factors, and cardiac medications. Results: In univariable analysis, caspase-3 associated with CAC (P < 0.0001), AWT (P = 0.002), and AC (P < 0.0001). After multivariable adjustment, 4th quartile caspase-3 (compared to 1st quartile) was significantly associated with CAC (P = 0.004), AWT (P = 0.02), and AC (P < 0.0001) with similar findings for caspase-3 as a continuous variable. Conclusions: Caspase-3 independently associates with CAC, AWT, and AC, suggesting a link between apoptosis and atherosclerosis.

AB - Background: Caspase-3, an apoptosis protease, is expressed in atherosclerotic plaques. We examined the relationship between plasma caspase-3 levels, aortic compliance, and atherosclerosis. Methods: Caspase-3 was measured in 3,221 subjects from the Dallas Heart Study. Electron beam computed tomography measures of coronary calcium (CAC) (n = 2,404) and magnetic resonance imaging (MRI) measures of abdominal aortic wall thickness (AWT) (n = 2,208) and aortic compliance (AC) (n = 2,328) were obtained. Multivariate analyses were performed, adjusting for age, sex, ethnicity, body mass index (BMI), traditional cardiovascular risk factors, and cardiac medications. Results: In univariable analysis, caspase-3 associated with CAC (P < 0.0001), AWT (P = 0.002), and AC (P < 0.0001). After multivariable adjustment, 4th quartile caspase-3 (compared to 1st quartile) was significantly associated with CAC (P = 0.004), AWT (P = 0.02), and AC (P < 0.0001) with similar findings for caspase-3 as a continuous variable. Conclusions: Caspase-3 independently associates with CAC, AWT, and AC, suggesting a link between apoptosis and atherosclerosis.

KW - Apoptosis

KW - Atherosclerosis

KW - Biological markers

KW - Human

KW - Magnetic resonance imaging

KW - Tomography

KW - X-ray computed

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VL - 13

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JO - Apoptosis : an international journal on programmed cell death

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SN - 1360-8185

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