TY - JOUR
T1 - The association between plasma caspase-3, atherosclerosis, and vascular function in the Dallas Heart Study
AU - Matulevicius, Susan A
AU - Rohatgi, Anand K
AU - Khera, Amit
AU - Das, Sandeep R
AU - Owens, Andrew
AU - Ayers, Colby R.
AU - Timaran, Carlos H
AU - Rosero, Eric B
AU - Drazner, Mark H
AU - Peshock, Ronald M
AU - de Lemos, James A
PY - 2008/10
Y1 - 2008/10
N2 - Background: Caspase-3, an apoptosis protease, is expressed in atherosclerotic plaques. We examined the relationship between plasma caspase-3 levels, aortic compliance, and atherosclerosis. Methods: Caspase-3 was measured in 3,221 subjects from the Dallas Heart Study. Electron beam computed tomography measures of coronary calcium (CAC) (n = 2,404) and magnetic resonance imaging (MRI) measures of abdominal aortic wall thickness (AWT) (n = 2,208) and aortic compliance (AC) (n = 2,328) were obtained. Multivariate analyses were performed, adjusting for age, sex, ethnicity, body mass index (BMI), traditional cardiovascular risk factors, and cardiac medications. Results: In univariable analysis, caspase-3 associated with CAC (P < 0.0001), AWT (P = 0.002), and AC (P < 0.0001). After multivariable adjustment, 4th quartile caspase-3 (compared to 1st quartile) was significantly associated with CAC (P = 0.004), AWT (P = 0.02), and AC (P < 0.0001) with similar findings for caspase-3 as a continuous variable. Conclusions: Caspase-3 independently associates with CAC, AWT, and AC, suggesting a link between apoptosis and atherosclerosis.
AB - Background: Caspase-3, an apoptosis protease, is expressed in atherosclerotic plaques. We examined the relationship between plasma caspase-3 levels, aortic compliance, and atherosclerosis. Methods: Caspase-3 was measured in 3,221 subjects from the Dallas Heart Study. Electron beam computed tomography measures of coronary calcium (CAC) (n = 2,404) and magnetic resonance imaging (MRI) measures of abdominal aortic wall thickness (AWT) (n = 2,208) and aortic compliance (AC) (n = 2,328) were obtained. Multivariate analyses were performed, adjusting for age, sex, ethnicity, body mass index (BMI), traditional cardiovascular risk factors, and cardiac medications. Results: In univariable analysis, caspase-3 associated with CAC (P < 0.0001), AWT (P = 0.002), and AC (P < 0.0001). After multivariable adjustment, 4th quartile caspase-3 (compared to 1st quartile) was significantly associated with CAC (P = 0.004), AWT (P = 0.02), and AC (P < 0.0001) with similar findings for caspase-3 as a continuous variable. Conclusions: Caspase-3 independently associates with CAC, AWT, and AC, suggesting a link between apoptosis and atherosclerosis.
KW - Apoptosis
KW - Atherosclerosis
KW - Biological markers
KW - Human
KW - Magnetic resonance imaging
KW - Tomography
KW - X-ray computed
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U2 - 10.1007/s10495-008-0254-1
DO - 10.1007/s10495-008-0254-1
M3 - Article
C2 - 18763039
AN - SCOPUS:51749102133
SN - 1360-8185
VL - 13
SP - 1281
EP - 1289
JO - Apoptosis
JF - Apoptosis
IS - 10
ER -