Abstract
Background: Women may become pregnant while using contraceptives. Commonly used contraceptives containing spermicides may or may not be associated with an increased occurrence of structural birth defects. Study Design: Utilizing data from the National Birth Defects Prevention Study, we assessed maternal reports of spermicide and male condom use 1 to 3 months following conception among case (n=11,050) and control (n=4723) mothers. We assessed the association between spermicide use and 27 types of birth defects and that between condom use and 32 types of birth defects. Results: Maternal spermicide use during the first 3 months following conception was associated with a significant increase in the occurrence of only 1 of 27 birth defects, perimembranous ventricular septal defects (adjusted odds ratio=2.40, 95% confidence interval=1.25-4.62). There was no significant association between maternal use of male condoms during the first 3 months following conception and any of 32 types of birth defects. Conclusions: The increased occurrence of perimembranous ventricular septal defects among spermicide users may be real or may be a chance finding. Overall, the findings are consistent with those of most previous studies that observed no increased risk for birth defects among spermicide users.
Original language | English (US) |
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Pages (from-to) | 422-429 |
Number of pages | 8 |
Journal | Contraception |
Volume | 80 |
Issue number | 5 |
DOIs | |
State | Published - Nov 2009 |
Keywords
- Birth defects
- Case-control study
- Congenital anomaly
- Contraception
- Male condoms
- Spermicides
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology