The association of allergic sensitization with radiographic sinus opacification

Christopher D. Brook, Jacob E. Kuperstock, Samuel J. Rubin, Matthew W. Ryan, Michael P. Platt

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: The relationship between allergic sensitization and radiographic sinus inflammation remains unclear. Objectives: To determine whether specific allergen sensitization is correlated with sinonasal radiographic opacification. Methods: Patients with chronic sinonasal symptoms were selected and included if they had allergy testing and a computed tomography (CT) of the paranasal sinuses. Data regarding demographic characteristics, in vitro allergy test results, and comorbidities were collected. CTs were reviewed, and an overall LundMackay score (LMS) was calculated for each patient. A twosample ttest was used to compare mean LMS between patients who were sensitized and patients who were not sensitized. A multiple linear regression model was used to determine whether a relationship existed among LMS and allergy results, asthma, nasal polyps, immunoglobulin E (IgE) level, medication usage, inseason versus outofseason CTs, age, and sex. Significance was determined at an alpha level of 0.05. Results: There were 437 patients included, of whom, 251 had positive specific allergen test results and 186 had negative test results. A total of 282 patients had allergic rhinitis symptoms without a documented diagnosis of sinusitis, and 155 carried a diagnosis of chronic rhinosinusitis. The mean LMS did not differ between patients who were sensitized and patients who were not sensitized (5.56 versus 5.28; p = 0.61). Linear regression demonstrated an increase in LMS in patients with asthma (p = 0.02), male sex (p < 0.01), elevated IgE (p < 0.01), a history of anaphylaxis (p = 0.03), and nasal polyps (p < 0.01). There was a statistically significant decrease in LMS in patients with an inseason CT (p = 0.02). Conclusion: Patients with a positive specific in vitro allergen test result did not have higher overall rates of radiographic sinus inflammation. Asthma, male sex, polyps, elevated IgE, and a history of anaphylaxis were associated with higher LMS.

Original languageEnglish (US)
Pages (from-to)12-15
Number of pages4
JournalAmerican Journal of Rhinology and Allergy
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Allergens
Immunoglobulin E
Linear Models
Hypersensitivity
Anaphylaxis
Asthma
Tomography
Inflammation
Nasal Polyps
Paranasal Sinuses
Sinusitis
Polyps
Comorbidity
Demography
In Vitro Techniques
Allergic Rhinitis
Asthma and Nasal Polyps

Keywords

  • Allergic rhinitis
  • Allergic sensitization
  • Atopy
  • Chronic sinusitis
  • Computed tomography
  • Nasal polyps
  • Sinusitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Otorhinolaryngology

Cite this

The association of allergic sensitization with radiographic sinus opacification. / Brook, Christopher D.; Kuperstock, Jacob E.; Rubin, Samuel J.; Ryan, Matthew W.; Platt, Michael P.

In: American Journal of Rhinology and Allergy, Vol. 31, No. 1, 01.01.2017, p. 12-15.

Research output: Contribution to journalArticle

Brook, Christopher D. ; Kuperstock, Jacob E. ; Rubin, Samuel J. ; Ryan, Matthew W. ; Platt, Michael P. / The association of allergic sensitization with radiographic sinus opacification. In: American Journal of Rhinology and Allergy. 2017 ; Vol. 31, No. 1. pp. 12-15.
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N2 - Background: The relationship between allergic sensitization and radiographic sinus inflammation remains unclear. Objectives: To determine whether specific allergen sensitization is correlated with sinonasal radiographic opacification. Methods: Patients with chronic sinonasal symptoms were selected and included if they had allergy testing and a computed tomography (CT) of the paranasal sinuses. Data regarding demographic characteristics, in vitro allergy test results, and comorbidities were collected. CTs were reviewed, and an overall LundMackay score (LMS) was calculated for each patient. A twosample ttest was used to compare mean LMS between patients who were sensitized and patients who were not sensitized. A multiple linear regression model was used to determine whether a relationship existed among LMS and allergy results, asthma, nasal polyps, immunoglobulin E (IgE) level, medication usage, inseason versus outofseason CTs, age, and sex. Significance was determined at an alpha level of 0.05. Results: There were 437 patients included, of whom, 251 had positive specific allergen test results and 186 had negative test results. A total of 282 patients had allergic rhinitis symptoms without a documented diagnosis of sinusitis, and 155 carried a diagnosis of chronic rhinosinusitis. The mean LMS did not differ between patients who were sensitized and patients who were not sensitized (5.56 versus 5.28; p = 0.61). Linear regression demonstrated an increase in LMS in patients with asthma (p = 0.02), male sex (p < 0.01), elevated IgE (p < 0.01), a history of anaphylaxis (p = 0.03), and nasal polyps (p < 0.01). There was a statistically significant decrease in LMS in patients with an inseason CT (p = 0.02). Conclusion: Patients with a positive specific in vitro allergen test result did not have higher overall rates of radiographic sinus inflammation. Asthma, male sex, polyps, elevated IgE, and a history of anaphylaxis were associated with higher LMS.

AB - Background: The relationship between allergic sensitization and radiographic sinus inflammation remains unclear. Objectives: To determine whether specific allergen sensitization is correlated with sinonasal radiographic opacification. Methods: Patients with chronic sinonasal symptoms were selected and included if they had allergy testing and a computed tomography (CT) of the paranasal sinuses. Data regarding demographic characteristics, in vitro allergy test results, and comorbidities were collected. CTs were reviewed, and an overall LundMackay score (LMS) was calculated for each patient. A twosample ttest was used to compare mean LMS between patients who were sensitized and patients who were not sensitized. A multiple linear regression model was used to determine whether a relationship existed among LMS and allergy results, asthma, nasal polyps, immunoglobulin E (IgE) level, medication usage, inseason versus outofseason CTs, age, and sex. Significance was determined at an alpha level of 0.05. Results: There were 437 patients included, of whom, 251 had positive specific allergen test results and 186 had negative test results. A total of 282 patients had allergic rhinitis symptoms without a documented diagnosis of sinusitis, and 155 carried a diagnosis of chronic rhinosinusitis. The mean LMS did not differ between patients who were sensitized and patients who were not sensitized (5.56 versus 5.28; p = 0.61). Linear regression demonstrated an increase in LMS in patients with asthma (p = 0.02), male sex (p < 0.01), elevated IgE (p < 0.01), a history of anaphylaxis (p = 0.03), and nasal polyps (p < 0.01). There was a statistically significant decrease in LMS in patients with an inseason CT (p = 0.02). Conclusion: Patients with a positive specific in vitro allergen test result did not have higher overall rates of radiographic sinus inflammation. Asthma, male sex, polyps, elevated IgE, and a history of anaphylaxis were associated with higher LMS.

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KW - Allergic sensitization

KW - Atopy

KW - Chronic sinusitis

KW - Computed tomography

KW - Nasal polyps

KW - Sinusitis

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