The association of maximum Troponin values post out-of-hospital cardiac arrest with electrocardiographic findings, cardiac reperfusion procedures and survival to discharge: A sub-study of ROC PRIMED

Laurie J. Morrison, Sean M. Devlin, Michael C. Kontos, Sheldon Cheskes, Tom P. Aufderheide, Jim Christenson, Joseph P. Ornato, Ian G. Stiell, Valeria E. Rac, Andrew J. Thomas, Jane G. Wigginton, Paul Dorian

Research output: Contribution to journalArticle

Abstract

Background The role of Troponin (Tn) levels in the management of patients post out-of-hospital cardiac arrest (OHCA) is unclear. Methods All OHCA patients enrolled in the Resuscitation Outcomes Consortium Prehospital Resuscitation using an IMpedance valve and Early versus Delayed analysis trial and admitted to hospital with a Tn level and a 12-lead electrocardiogram were stratified by ST elevation (STE) or no STE in a regression model for survival to discharge adjusted for Utstein predictors and site. Results Of the 15,617 enrolled OHCA patients, 4118 (26%) survived to admission to hospital; 17% (693) were STE and 77% (3188) were no STE with 6% unknown; 83% (3460) had at least one Tn level. Reperfusion rates were higher when Tn level >2 ng/ml (p > 0.1 ng/ml) improved with a diagnostic cardiac catheterization (p < 0.001). Conclusions Elevated Tn levels >2 ng/ml were associated with improved survival to discharge in patients post OHCA with STE. Survival in patients with no STE and Tn values >0.1 ng/ml was higher when associated with diagnostic cardiac catheterization or treated with reperfusion or revascularization.

Original languageEnglish (US)
Pages (from-to)82-89
Number of pages8
JournalResuscitation
Volume111
DOIs
StatePublished - Feb 1 2017

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Out-of-Hospital Cardiac Arrest
Troponin
Reperfusion
Survival
Cardiac Catheterization
Resuscitation
Patient Discharge
Electric Impedance
Electrocardiography

Keywords

  • Angiography
  • Cardiopulmonary resuscitation
  • Fibrinolysis
  • Heart arrest
  • Thrombolysis

ASJC Scopus subject areas

  • Emergency Medicine
  • Emergency
  • Cardiology and Cardiovascular Medicine

Cite this

The association of maximum Troponin values post out-of-hospital cardiac arrest with electrocardiographic findings, cardiac reperfusion procedures and survival to discharge : A sub-study of ROC PRIMED. / Morrison, Laurie J.; Devlin, Sean M.; Kontos, Michael C.; Cheskes, Sheldon; Aufderheide, Tom P.; Christenson, Jim; Ornato, Joseph P.; Stiell, Ian G.; Rac, Valeria E.; Thomas, Andrew J.; Wigginton, Jane G.; Dorian, Paul.

In: Resuscitation, Vol. 111, 01.02.2017, p. 82-89.

Research output: Contribution to journalArticle

Morrison, Laurie J. ; Devlin, Sean M. ; Kontos, Michael C. ; Cheskes, Sheldon ; Aufderheide, Tom P. ; Christenson, Jim ; Ornato, Joseph P. ; Stiell, Ian G. ; Rac, Valeria E. ; Thomas, Andrew J. ; Wigginton, Jane G. ; Dorian, Paul. / The association of maximum Troponin values post out-of-hospital cardiac arrest with electrocardiographic findings, cardiac reperfusion procedures and survival to discharge : A sub-study of ROC PRIMED. In: Resuscitation. 2017 ; Vol. 111. pp. 82-89.
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abstract = "Background The role of Troponin (Tn) levels in the management of patients post out-of-hospital cardiac arrest (OHCA) is unclear. Methods All OHCA patients enrolled in the Resuscitation Outcomes Consortium Prehospital Resuscitation using an IMpedance valve and Early versus Delayed analysis trial and admitted to hospital with a Tn level and a 12-lead electrocardiogram were stratified by ST elevation (STE) or no STE in a regression model for survival to discharge adjusted for Utstein predictors and site. Results Of the 15,617 enrolled OHCA patients, 4118 (26{\%}) survived to admission to hospital; 17{\%} (693) were STE and 77{\%} (3188) were no STE with 6{\%} unknown; 83{\%} (3460) had at least one Tn level. Reperfusion rates were higher when Tn level >2 ng/ml (p > 0.1 ng/ml) improved with a diagnostic cardiac catheterization (p < 0.001). Conclusions Elevated Tn levels >2 ng/ml were associated with improved survival to discharge in patients post OHCA with STE. Survival in patients with no STE and Tn values >0.1 ng/ml was higher when associated with diagnostic cardiac catheterization or treated with reperfusion or revascularization.",
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