The basic science of wound healing

George Broughton, Jeffrey E. Janis, Christopher E. Attinger

Research output: Contribution to journalReview articlepeer-review

737 Scopus citations

Abstract

Understanding wound healing today involves much more than simply stating that there are three phases: "inflammation, proliferation, and maturation." Wound healing is a complex series of reactions and interactions among cells and "mediators." Each year, new mediators are discovered and our understanding of inflammatory mediators and cellular interactions grows. This article will attempt to provide a concise report of the current literature on wound healing by first reviewing the phases of wound healing followed by "the players" of wound healing: inflammatory mediators (cytokines, growth factors, proteases, eicosanoids, kinins, and more), nitric oxide, and the cellular elements. The discussion will end with a pictorial essay summarizing the wound-healing process.

Original languageEnglish (US)
Pages (from-to)12S-34S
JournalPlastic and reconstructive surgery
Volume117
Issue number7 SUPPL.
DOIs
StatePublished - Jun 1 2006

ASJC Scopus subject areas

  • Surgery

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