The Beclin 1 interactome

Congcong He, Beth Levine

Research output: Contribution to journalArticle

395 Citations (Scopus)

Abstract

The mammalian ortholog of yeast Atg6/Vps30, Beclin 1, is an essential autophagy protein that has been linked to diverse biological processes, including immunity, development, tumor suppression, lifespan extension, and protection against certain cardiac and neurodegenerative diseases. In recent years, major advances have been made in identifying components of functionally distinct Beclin 1/class III phosphatidylinositol 3-kinase complexes, in characterizing the molecular regulation of interactions between Beclin 1 and the autophagy inhibitors, Bcl-2/BcL-XL, and in uncovering a role for viral antagonists of Beclin 1 in viral pathogenesis. The rapidly growing list of components of the 'Beclin 1 interactome' supports a model in which autophagy, and potentially other membrane trafficking functions of Beclin 1, are governed by differential interactions with different binding partners in different physiological or pathophysiological contexts.

Original languageEnglish (US)
Pages (from-to)140-149
Number of pages10
JournalCurrent Opinion in Cell Biology
Volume22
Issue number2
DOIs
StatePublished - Apr 2010

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Autophagy
Class III Phosphatidylinositol 3-Kinases
Biological Phenomena
Neurodegenerative Diseases
Beclin-1
Immunity
Heart Diseases
Yeasts
Membranes
Neoplasms
Proteins

ASJC Scopus subject areas

  • Cell Biology

Cite this

The Beclin 1 interactome. / He, Congcong; Levine, Beth.

In: Current Opinion in Cell Biology, Vol. 22, No. 2, 04.2010, p. 140-149.

Research output: Contribution to journalArticle

He, Congcong ; Levine, Beth. / The Beclin 1 interactome. In: Current Opinion in Cell Biology. 2010 ; Vol. 22, No. 2. pp. 140-149.
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