TY - CHAP
T1 - The Biochemistry of Endothelial Cells
AU - Savani, Rashmin C.
N1 - Funding Information:
I want to thank the following for giving permission to use schematics or photomicrographs that were either generated or modified from their work: Dr Philip Shaul for the schematic of localization of eNOS in caveolae ( Figure 3 ); Dr Vincent Hascall (Cleveland Clinic) for the schematic of HA structure ( Figure 5(A) ); Dr Horace M. DeLisser for the electron micrograph images ( Figure 7 ). I also gratefully acknowledge funding from the National Institutes of Health (HL62868, HL62472, HL075930, HL075900, HL093535), Children's Medical Center Foundation (Dallas), and The William Buchanan Chair in Pediatrics of the University of Texas Southwestern Medical Center that shaped much of the work from my laboratory that is cited in this chapter. I also wish to acknowledge the donation of NO to my laboratory by Ikaria Therapeutics through an independent research agreement.
PY - 2015/3/18
Y1 - 2015/3/18
N2 - The last two decades have seen enormous progress in vascular endothelial cell biology with significant advances in our understanding of the regulation of endothelial cell functions, the discovery and extensive study of endothelial cell relaxation and constriction factors, in particular nitric oxide, and the biology of nitric oxide synthases. Physiologic and pathophysiologic roles for endothelial cells in vascular smooth muscle cell physiology, vasodilatation, permeability, mechanosensation and mechanotransduction, leukocyte recruitment, and thrombosis have also been defined. Importantly, these mechanistic insights have led to more detailed understanding of how endothelial cells contribute to angiogenesis, lung and vascular development, tumor growth and metastasis, diabetes and insulin resistance, atherosclerosis, retinopathies, and the antiphospholipid syndrome.
AB - The last two decades have seen enormous progress in vascular endothelial cell biology with significant advances in our understanding of the regulation of endothelial cell functions, the discovery and extensive study of endothelial cell relaxation and constriction factors, in particular nitric oxide, and the biology of nitric oxide synthases. Physiologic and pathophysiologic roles for endothelial cells in vascular smooth muscle cell physiology, vasodilatation, permeability, mechanosensation and mechanotransduction, leukocyte recruitment, and thrombosis have also been defined. Importantly, these mechanistic insights have led to more detailed understanding of how endothelial cells contribute to angiogenesis, lung and vascular development, tumor growth and metastasis, diabetes and insulin resistance, atherosclerosis, retinopathies, and the antiphospholipid syndrome.
KW - Angiogenesis
KW - Atherosclerosis
KW - Diabetes
KW - Endothelial cells
KW - Inflammation
KW - Nitric oxide
KW - Vascular development
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U2 - 10.1016/B978-0-12-404577-4.00019-9
DO - 10.1016/B978-0-12-404577-4.00019-9
M3 - Chapter
AN - SCOPUS:84939608151
SN - 9780124047266
SP - 375
EP - 386
BT - Comparative Biology of the Normal Lung
PB - Elsevier Inc.
ER -