Abstract
The last two decades have seen enormous progress in vascular endothelial cell biology with significant advances in our understanding of the regulation of endothelial cell functions, the discovery and extensive study of endothelial cell relaxation and constriction factors, in particular nitric oxide, and the biology of nitric oxide synthases. Physiologic and pathophysiologic roles for endothelial cells in vascular smooth muscle cell physiology, vasodilatation, permeability, mechanosensation and mechanotransduction, leukocyte recruitment, and thrombosis have also been defined. Importantly, these mechanistic insights have led to more detailed understanding of how endothelial cells contribute to angiogenesis, lung and vascular development, tumor growth and metastasis, diabetes and insulin resistance, atherosclerosis, retinopathies, and the antiphospholipid syndrome.
| Original language | English (US) |
|---|---|
| Title of host publication | Comparative Biology of the Normal Lung: Second Edition |
| Publisher | Elsevier Inc. |
| Pages | 375-386 |
| Number of pages | 12 |
| ISBN (Print) | 9780124045774, 9780124047266 |
| DOIs | |
| State | Published - Mar 18 2015 |
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Keywords
- Angiogenesis
- Atherosclerosis
- Diabetes
- Endothelial cells
- Inflammation
- Nitric oxide
- Vascular development
ASJC Scopus subject areas
- Medicine(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
The Biochemistry of Endothelial Cells. / Savani, Rashmin C.
Comparative Biology of the Normal Lung: Second Edition. Elsevier Inc., 2015. p. 375-386.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - The Biochemistry of Endothelial Cells
AU - Savani, Rashmin C.
PY - 2015/3/18
Y1 - 2015/3/18
N2 - The last two decades have seen enormous progress in vascular endothelial cell biology with significant advances in our understanding of the regulation of endothelial cell functions, the discovery and extensive study of endothelial cell relaxation and constriction factors, in particular nitric oxide, and the biology of nitric oxide synthases. Physiologic and pathophysiologic roles for endothelial cells in vascular smooth muscle cell physiology, vasodilatation, permeability, mechanosensation and mechanotransduction, leukocyte recruitment, and thrombosis have also been defined. Importantly, these mechanistic insights have led to more detailed understanding of how endothelial cells contribute to angiogenesis, lung and vascular development, tumor growth and metastasis, diabetes and insulin resistance, atherosclerosis, retinopathies, and the antiphospholipid syndrome.
AB - The last two decades have seen enormous progress in vascular endothelial cell biology with significant advances in our understanding of the regulation of endothelial cell functions, the discovery and extensive study of endothelial cell relaxation and constriction factors, in particular nitric oxide, and the biology of nitric oxide synthases. Physiologic and pathophysiologic roles for endothelial cells in vascular smooth muscle cell physiology, vasodilatation, permeability, mechanosensation and mechanotransduction, leukocyte recruitment, and thrombosis have also been defined. Importantly, these mechanistic insights have led to more detailed understanding of how endothelial cells contribute to angiogenesis, lung and vascular development, tumor growth and metastasis, diabetes and insulin resistance, atherosclerosis, retinopathies, and the antiphospholipid syndrome.
KW - Angiogenesis
KW - Atherosclerosis
KW - Diabetes
KW - Endothelial cells
KW - Inflammation
KW - Nitric oxide
KW - Vascular development
UR - http://www.scopus.com/inward/record.url?scp=84939608151&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84939608151&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-404577-4.00019-9
DO - 10.1016/B978-0-12-404577-4.00019-9
M3 - Chapter
AN - SCOPUS:84939608151
SN - 9780124045774
SN - 9780124047266
SP - 375
EP - 386
BT - Comparative Biology of the Normal Lung: Second Edition
PB - Elsevier Inc.
ER -