TY - JOUR
T1 - The bioengineered kidney
T2 - Science or science fiction?
AU - Oxburgh, Leif
AU - Carroll, Thomas J.
N1 - Publisher Copyright:
© 2016 Wolters Kluwer Health, Inc.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Purpose of review This article gives an overview of important new advances relating to kidney bioengineering. Recent findings Directed differentiation studies have shown that proximal tubules, distal tubules, podocytes, collecting ducts, interstitium and endothelial cells can be generated from patient-derived stem cells using standardized protocols. One caveat to the interpretation of these studies is that the physiological characteristics of differentiated cells remain to be defined. Another important area of progress is scaffolding. Both decellularized organs and polymeric materials are being used as platforms for three-dimensional growth of kidney tissue, and key distinctions between these approaches are discussed. Summary In the past 3 years, it has become clear that building kidney tissue is feasible. The laboratory-grown kidney is an attainable goal if efforts are focused on refining directed differentiation procedures to optimize cell function and on developing scaffolding strategies that ensure physiological function at the tissue level.
AB - Purpose of review This article gives an overview of important new advances relating to kidney bioengineering. Recent findings Directed differentiation studies have shown that proximal tubules, distal tubules, podocytes, collecting ducts, interstitium and endothelial cells can be generated from patient-derived stem cells using standardized protocols. One caveat to the interpretation of these studies is that the physiological characteristics of differentiated cells remain to be defined. Another important area of progress is scaffolding. Both decellularized organs and polymeric materials are being used as platforms for three-dimensional growth of kidney tissue, and key distinctions between these approaches are discussed. Summary In the past 3 years, it has become clear that building kidney tissue is feasible. The laboratory-grown kidney is an attainable goal if efforts are focused on refining directed differentiation procedures to optimize cell function and on developing scaffolding strategies that ensure physiological function at the tissue level.
KW - directed differentiation
KW - laboratory-grown tissue
KW - organogenesis
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U2 - 10.1097/MNH.0000000000000235
DO - 10.1097/MNH.0000000000000235
M3 - Review article
C2 - 27166519
AN - SCOPUS:84966697289
SN - 1062-4821
VL - 25
SP - 343
EP - 347
JO - Current opinion in nephrology and hypertension
JF - Current opinion in nephrology and hypertension
IS - 4
ER -