The biological effectiveness of antiproton irradiation

Michael H. Holzscheiter, Niels Bassler, Nzhde Agazaryan, Gerd Beyer, Ewart Blackmore, John J. DeMarco, Michael Doser, Ralph E. Durand, Oliver Hartley, Keisuke S. Iwamoto, Helge V. Knudsen, Rolf Landua, Carl Maggiore, William H. McBride, Søren Pape Møller, Jørgen Petersen, Lloyd D. Skarsgard, James B. Smathers, Timothy D. Solberg, Ulrik I. UggerhøjSanja Vranjes, H. Rodney Withers, Michelle Wong, Bradly G. Wouters

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Background and purpose: Antiprotons travel through tissue in a manner similar to that for protons until they reach the end of their range where they annihilate and deposit additional energy. This makes them potentially interesting for radiotherapy. The aim of this study was to conduct the first ever measurements of the biological effectiveness of antiprotons. Materials and methods: V79 cells were suspended in a semi-solid matrix and irradiated with 46.7 MeV antiprotons, 48 MeV protons, or 60Co γ-rays. Clonogenic survival was determined as a function of depth along the particle beams. Dose and particle fluence response relationships were constructed from data in the plateau and Bragg peak regions of the beams and used to assess the biological effectiveness. Results: Due to uncertainties in antiproton dosimetry we defined a new term, called the biologically effective dose ratio (BEDR), which compares the response in a minimally spread out Bragg peak (SOBP) to that in the plateau as a function of particle fluence. This value was ∼3.75 times larger for antiprotons than for protons. This increase arises due to the increased dose deposited in the Bragg peak by annihilation and because this dose has a higher relative biological effectiveness (RBE). Conclusion: We have produced the first measurements of the biological consequences of antiproton irradiation. These data substantiate theoretical predictions of the biological effects of antiproton annihilation within the Bragg peak, and suggest antiprotons warrant further investigation.

Original languageEnglish (US)
Pages (from-to)233-242
Number of pages10
JournalRadiotherapy and Oncology
Volume81
Issue number3
DOIs
StatePublished - Dec 2006

Fingerprint

Protons
Relative Biological Effectiveness
Uncertainty
Radiotherapy

Keywords

  • Antiproton
  • High LET
  • Particle irradiation
  • RBE

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Urology

Cite this

Holzscheiter, M. H., Bassler, N., Agazaryan, N., Beyer, G., Blackmore, E., DeMarco, J. J., ... Wouters, B. G. (2006). The biological effectiveness of antiproton irradiation. Radiotherapy and Oncology, 81(3), 233-242. https://doi.org/10.1016/j.radonc.2006.09.012

The biological effectiveness of antiproton irradiation. / Holzscheiter, Michael H.; Bassler, Niels; Agazaryan, Nzhde; Beyer, Gerd; Blackmore, Ewart; DeMarco, John J.; Doser, Michael; Durand, Ralph E.; Hartley, Oliver; Iwamoto, Keisuke S.; Knudsen, Helge V.; Landua, Rolf; Maggiore, Carl; McBride, William H.; Møller, Søren Pape; Petersen, Jørgen; Skarsgard, Lloyd D.; Smathers, James B.; Solberg, Timothy D.; Uggerhøj, Ulrik I.; Vranjes, Sanja; Withers, H. Rodney; Wong, Michelle; Wouters, Bradly G.

In: Radiotherapy and Oncology, Vol. 81, No. 3, 12.2006, p. 233-242.

Research output: Contribution to journalArticle

Holzscheiter, MH, Bassler, N, Agazaryan, N, Beyer, G, Blackmore, E, DeMarco, JJ, Doser, M, Durand, RE, Hartley, O, Iwamoto, KS, Knudsen, HV, Landua, R, Maggiore, C, McBride, WH, Møller, SP, Petersen, J, Skarsgard, LD, Smathers, JB, Solberg, TD, Uggerhøj, UI, Vranjes, S, Withers, HR, Wong, M & Wouters, BG 2006, 'The biological effectiveness of antiproton irradiation', Radiotherapy and Oncology, vol. 81, no. 3, pp. 233-242. https://doi.org/10.1016/j.radonc.2006.09.012
Holzscheiter MH, Bassler N, Agazaryan N, Beyer G, Blackmore E, DeMarco JJ et al. The biological effectiveness of antiproton irradiation. Radiotherapy and Oncology. 2006 Dec;81(3):233-242. https://doi.org/10.1016/j.radonc.2006.09.012
Holzscheiter, Michael H. ; Bassler, Niels ; Agazaryan, Nzhde ; Beyer, Gerd ; Blackmore, Ewart ; DeMarco, John J. ; Doser, Michael ; Durand, Ralph E. ; Hartley, Oliver ; Iwamoto, Keisuke S. ; Knudsen, Helge V. ; Landua, Rolf ; Maggiore, Carl ; McBride, William H. ; Møller, Søren Pape ; Petersen, Jørgen ; Skarsgard, Lloyd D. ; Smathers, James B. ; Solberg, Timothy D. ; Uggerhøj, Ulrik I. ; Vranjes, Sanja ; Withers, H. Rodney ; Wong, Michelle ; Wouters, Bradly G. / The biological effectiveness of antiproton irradiation. In: Radiotherapy and Oncology. 2006 ; Vol. 81, No. 3. pp. 233-242.
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AU - Bassler, Niels

AU - Agazaryan, Nzhde

AU - Beyer, Gerd

AU - Blackmore, Ewart

AU - DeMarco, John J.

AU - Doser, Michael

AU - Durand, Ralph E.

AU - Hartley, Oliver

AU - Iwamoto, Keisuke S.

AU - Knudsen, Helge V.

AU - Landua, Rolf

AU - Maggiore, Carl

AU - McBride, William H.

AU - Møller, Søren Pape

AU - Petersen, Jørgen

AU - Skarsgard, Lloyd D.

AU - Smathers, James B.

AU - Solberg, Timothy D.

AU - Uggerhøj, Ulrik I.

AU - Vranjes, Sanja

AU - Withers, H. Rodney

AU - Wong, Michelle

AU - Wouters, Bradly G.

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N2 - Background and purpose: Antiprotons travel through tissue in a manner similar to that for protons until they reach the end of their range where they annihilate and deposit additional energy. This makes them potentially interesting for radiotherapy. The aim of this study was to conduct the first ever measurements of the biological effectiveness of antiprotons. Materials and methods: V79 cells were suspended in a semi-solid matrix and irradiated with 46.7 MeV antiprotons, 48 MeV protons, or 60Co γ-rays. Clonogenic survival was determined as a function of depth along the particle beams. Dose and particle fluence response relationships were constructed from data in the plateau and Bragg peak regions of the beams and used to assess the biological effectiveness. Results: Due to uncertainties in antiproton dosimetry we defined a new term, called the biologically effective dose ratio (BEDR), which compares the response in a minimally spread out Bragg peak (SOBP) to that in the plateau as a function of particle fluence. This value was ∼3.75 times larger for antiprotons than for protons. This increase arises due to the increased dose deposited in the Bragg peak by annihilation and because this dose has a higher relative biological effectiveness (RBE). Conclusion: We have produced the first measurements of the biological consequences of antiproton irradiation. These data substantiate theoretical predictions of the biological effects of antiproton annihilation within the Bragg peak, and suggest antiprotons warrant further investigation.

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